Cyclic urea derivatives as potent NK1 selective antagonists

Ho Jane Shue, Xiao Chen, Neng Yang Shih, David J. Blythin, Sunil Paliwal, Ling Lin, Danlin Gu, John H. Schwerdt, Sapna Shah, Gregory A. Reichard, John J. Piwinski, Ruth A. Duffy, Jean E. Lachowicz, Vicki L. Coffin, Fei Liu, Amin A. Nomeir, Cynthia A. Morgan, Geoffrey B. Varty

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compounds are also described herein.

Original languageEnglish (US)
Pages (from-to)3896-3899
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number17
DOIs
StatePublished - Sep 1 2005

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Urea
Brain
Derivatives

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Molecular Medicine
  • Molecular Biology
  • Biochemistry
  • Clinical Biochemistry
  • Pharmaceutical Science
  • Organic Chemistry

Cite this

Shue, H. J., Chen, X., Shih, N. Y., Blythin, D. J., Paliwal, S., Lin, L., ... Varty, G. B. (2005). Cyclic urea derivatives as potent NK1 selective antagonists. Bioorganic and Medicinal Chemistry Letters, 15(17), 3896-3899. https://doi.org/10.1016/j.bmcl.2005.05.111
Shue, Ho Jane ; Chen, Xiao ; Shih, Neng Yang ; Blythin, David J. ; Paliwal, Sunil ; Lin, Ling ; Gu, Danlin ; Schwerdt, John H. ; Shah, Sapna ; Reichard, Gregory A. ; Piwinski, John J. ; Duffy, Ruth A. ; Lachowicz, Jean E. ; Coffin, Vicki L. ; Liu, Fei ; Nomeir, Amin A. ; Morgan, Cynthia A. ; Varty, Geoffrey B. / Cyclic urea derivatives as potent NK1 selective antagonists. In: Bioorganic and Medicinal Chemistry Letters. 2005 ; Vol. 15, No. 17. pp. 3896-3899.
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Shue, HJ, Chen, X, Shih, NY, Blythin, DJ, Paliwal, S, Lin, L, Gu, D, Schwerdt, JH, Shah, S, Reichard, GA, Piwinski, JJ, Duffy, RA, Lachowicz, JE, Coffin, VL, Liu, F, Nomeir, AA, Morgan, CA & Varty, GB 2005, 'Cyclic urea derivatives as potent NK1 selective antagonists', Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 17, pp. 3896-3899. https://doi.org/10.1016/j.bmcl.2005.05.111

Cyclic urea derivatives as potent NK1 selective antagonists. / Shue, Ho Jane; Chen, Xiao; Shih, Neng Yang; Blythin, David J.; Paliwal, Sunil; Lin, Ling; Gu, Danlin; Schwerdt, John H.; Shah, Sapna; Reichard, Gregory A.; Piwinski, John J.; Duffy, Ruth A.; Lachowicz, Jean E.; Coffin, Vicki L.; Liu, Fei; Nomeir, Amin A.; Morgan, Cynthia A.; Varty, Geoffrey B.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 15, No. 17, 01.09.2005, p. 3896-3899.

Research output: Contribution to journalArticle

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AU - Shue, Ho Jane

AU - Chen, Xiao

AU - Shih, Neng Yang

AU - Blythin, David J.

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AU - Lin, Ling

AU - Gu, Danlin

AU - Schwerdt, John H.

AU - Shah, Sapna

AU - Reichard, Gregory A.

AU - Piwinski, John J.

AU - Duffy, Ruth A.

AU - Lachowicz, Jean E.

AU - Coffin, Vicki L.

AU - Liu, Fei

AU - Nomeir, Amin A.

AU - Morgan, Cynthia A.

AU - Varty, Geoffrey B.

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