Cytokine regulation of immunopathology in toxoplasmosis

Pamela J. Gaddi, George S. Yap

Research output: Contribution to journalReview articlepeer-review

77 Scopus citations

Abstract

Toxoplasma gondii infection is an important cause of central nervous system and ocular disease, both in immunocompromised and in certain immunocompetent populations. Although parasite-mediated host cell lysis is probably the principal cause of tissue destruction in immunodeficiency states, hypersensitivity and inflammatory responses may underlie severe disease in otherwise immuno-sufficient individuals. In this review, we have critically evaluated the body of experimental evidence indicating a role of CD4 T cells in systemic and local immunopathology associated with T. gondii infection. We also discuss the pathogenic roles of cytokines produced by T helper (Th) 1 and Th17 cells and the protective and homeostatic roles of interleukin (IL)-10, transforming growth factor-Β and IL-27 in modulating hypersensitivity responses induced by T. gondii.

Original languageEnglish (US)
Pages (from-to)155-159
Number of pages5
JournalImmunology and Cell Biology
Volume85
Issue number2
DOIs
StatePublished - Feb 5 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Cell Biology
  • Immunology

Keywords

  • IL-10
  • IL-12
  • IL-27
  • Immunopathology
  • TGF-β
  • Toxoplasmosis

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