Decoding cis-regulatory DNAs in the Drosophila genome

Michele Markstein, Michael Steven Levine

Research output: Contribution to journalReview article

55 Citations (Scopus)

Abstract

Cis-regulatory DNAs control the timing and sites of gene expression during metazoan development. Changes in gene expression are responsible for the morphological diversification of metazoan body plans. However, traditional methods for the identification and characterization of cis-regulatory DNAs are tedious. During the past year, computational methods have been used to identify novel cis-DNAs within the entire Drosophila genome. These methods change the way that cis-DNAs will be analyzed in future studies and offer the promise of unraveling complex gene networks.

Original languageEnglish (US)
Pages (from-to)601-606
Number of pages6
JournalCurrent Opinion in Genetics and Development
Volume12
Issue number5
DOIs
StatePublished - Oct 1 2002
Externally publishedYes

Fingerprint

Drosophila
Genome
DNA
Gene Expression
Gene Regulatory Networks

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

Cite this

@article{ea8151fa509f450bb27b15e22381e967,
title = "Decoding cis-regulatory DNAs in the Drosophila genome",
abstract = "Cis-regulatory DNAs control the timing and sites of gene expression during metazoan development. Changes in gene expression are responsible for the morphological diversification of metazoan body plans. However, traditional methods for the identification and characterization of cis-regulatory DNAs are tedious. During the past year, computational methods have been used to identify novel cis-DNAs within the entire Drosophila genome. These methods change the way that cis-DNAs will be analyzed in future studies and offer the promise of unraveling complex gene networks.",
author = "Michele Markstein and Levine, {Michael Steven}",
year = "2002",
month = "10",
day = "1",
doi = "https://doi.org/10.1016/S0959-437X(02)00345-3",
language = "English (US)",
volume = "12",
pages = "601--606",
journal = "Current Opinion in Genetics and Development",
issn = "0959-437X",
publisher = "Elsevier Limited",
number = "5",

}

Decoding cis-regulatory DNAs in the Drosophila genome. / Markstein, Michele; Levine, Michael Steven.

In: Current Opinion in Genetics and Development, Vol. 12, No. 5, 01.10.2002, p. 601-606.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Decoding cis-regulatory DNAs in the Drosophila genome

AU - Markstein, Michele

AU - Levine, Michael Steven

PY - 2002/10/1

Y1 - 2002/10/1

N2 - Cis-regulatory DNAs control the timing and sites of gene expression during metazoan development. Changes in gene expression are responsible for the morphological diversification of metazoan body plans. However, traditional methods for the identification and characterization of cis-regulatory DNAs are tedious. During the past year, computational methods have been used to identify novel cis-DNAs within the entire Drosophila genome. These methods change the way that cis-DNAs will be analyzed in future studies and offer the promise of unraveling complex gene networks.

AB - Cis-regulatory DNAs control the timing and sites of gene expression during metazoan development. Changes in gene expression are responsible for the morphological diversification of metazoan body plans. However, traditional methods for the identification and characterization of cis-regulatory DNAs are tedious. During the past year, computational methods have been used to identify novel cis-DNAs within the entire Drosophila genome. These methods change the way that cis-DNAs will be analyzed in future studies and offer the promise of unraveling complex gene networks.

UR - http://www.scopus.com/inward/record.url?scp=0036777340&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036777340&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/S0959-437X(02)00345-3

DO - https://doi.org/10.1016/S0959-437X(02)00345-3

M3 - Review article

VL - 12

SP - 601

EP - 606

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

SN - 0959-437X

IS - 5

ER -