Decreased DBC1 expression is associated with poor prognosis in patients with non-muscle-invasive bladder cancer

Ui Jae Shim, Il Seok Lee, Ho Won Kang, Jayoung Kim, Won Tae Kim, Isaac Kim, Keun Ho Ryu, Yung Hyun Choi, Sung Kwon Moon, Yong June Kim, Seok Joong Yun, Sang Cheol Lee, Wun Jae Kim

Research output: Contribution to journalArticle

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Abstract

Purpose: The deleted in bladder cancer 1 (DBC1) gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in bladder cancer (BC). It is suspected that it acts as a tumor suppressor gene, but its prognostic value remains unclear. The aim of the present study was to investigate the value of DBC1 as a prognostic marker in BC. Materials and Methods: The expression of DBC1 was determined by real-time polymer-ase chain reaction analysis in 344 patients with BC (220 non-muscle-invasive BC [NMIBC] and 124 muscle-invasive BC [MIBC]) and in 34 patients with normal bladder mucosa. The results were compared with clinicopathologic parameters, and the prognostic value of DBC1 was evaluated by Kaplan-Meier analysis and a multivariate Cox regression model. Results: DBC1 expression was significantly decreased in patients with MIBC compared with those diagnosed with NMIBC (p=0.010). Patients with aggressive tumor characteristics had lower DBC1 expression levels in NMIBC (each, p<0.05). By multivariate Cox regression analysis, low DBC1 expression was a predictor of progression to MIBC (hazard ratio, 7.104; p=0.013). Kaplan-Meier estimates revealed a significant difference in tumor recurrence, progression to MIBC, and cancer-specific survival depending on the level of DBC1 expression in NMIBC (log-rank test, each, p<0.05). Conclusions: The expression of DBC1 was associated with tumor aggressiveness, progression to MIBC, and survival in NMIBC. Our results suggest that DBC1 expression can be a useful prognostic marker for patients with NMIBC.

Original languageEnglish (US)
Pages (from-to)631-637
Number of pages7
JournalKorean Journal of Urology
Volume54
Issue number9
DOIs
StatePublished - Sep 1 2013

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Urinary Bladder Neoplasms
Muscles
Kaplan-Meier Estimate
Neoplasms
Muscle Neoplasms
Chromosomes, Human, Pair 9
Survival
Loss of Heterozygosity
Neoplasm Genes
Tumor Suppressor Genes
Proportional Hazards Models
Polymers
Mucous Membrane
Urinary Bladder
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Urology

Keywords

  • Bladder cancer
  • Human DBC1 protein
  • Prognosis

Cite this

Shim, Ui Jae ; Lee, Il Seok ; Kang, Ho Won ; Kim, Jayoung ; Kim, Won Tae ; Kim, Isaac ; Ryu, Keun Ho ; Choi, Yung Hyun ; Moon, Sung Kwon ; Kim, Yong June ; Yun, Seok Joong ; Lee, Sang Cheol ; Kim, Wun Jae. / Decreased DBC1 expression is associated with poor prognosis in patients with non-muscle-invasive bladder cancer. In: Korean Journal of Urology. 2013 ; Vol. 54, No. 9. pp. 631-637.
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title = "Decreased DBC1 expression is associated with poor prognosis in patients with non-muscle-invasive bladder cancer",
abstract = "Purpose: The deleted in bladder cancer 1 (DBC1) gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in bladder cancer (BC). It is suspected that it acts as a tumor suppressor gene, but its prognostic value remains unclear. The aim of the present study was to investigate the value of DBC1 as a prognostic marker in BC. Materials and Methods: The expression of DBC1 was determined by real-time polymer-ase chain reaction analysis in 344 patients with BC (220 non-muscle-invasive BC [NMIBC] and 124 muscle-invasive BC [MIBC]) and in 34 patients with normal bladder mucosa. The results were compared with clinicopathologic parameters, and the prognostic value of DBC1 was evaluated by Kaplan-Meier analysis and a multivariate Cox regression model. Results: DBC1 expression was significantly decreased in patients with MIBC compared with those diagnosed with NMIBC (p=0.010). Patients with aggressive tumor characteristics had lower DBC1 expression levels in NMIBC (each, p<0.05). By multivariate Cox regression analysis, low DBC1 expression was a predictor of progression to MIBC (hazard ratio, 7.104; p=0.013). Kaplan-Meier estimates revealed a significant difference in tumor recurrence, progression to MIBC, and cancer-specific survival depending on the level of DBC1 expression in NMIBC (log-rank test, each, p<0.05). Conclusions: The expression of DBC1 was associated with tumor aggressiveness, progression to MIBC, and survival in NMIBC. Our results suggest that DBC1 expression can be a useful prognostic marker for patients with NMIBC.",
keywords = "Bladder cancer, Human DBC1 protein, Prognosis",
author = "Shim, {Ui Jae} and Lee, {Il Seok} and Kang, {Ho Won} and Jayoung Kim and Kim, {Won Tae} and Isaac Kim and Ryu, {Keun Ho} and Choi, {Yung Hyun} and Moon, {Sung Kwon} and Kim, {Yong June} and Yun, {Seok Joong} and Lee, {Sang Cheol} and Kim, {Wun Jae}",
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Shim, UJ, Lee, IS, Kang, HW, Kim, J, Kim, WT, Kim, I, Ryu, KH, Choi, YH, Moon, SK, Kim, YJ, Yun, SJ, Lee, SC & Kim, WJ 2013, 'Decreased DBC1 expression is associated with poor prognosis in patients with non-muscle-invasive bladder cancer', Korean Journal of Urology, vol. 54, no. 9, pp. 631-637. https://doi.org/10.4111/kju.2013.54.9.631

Decreased DBC1 expression is associated with poor prognosis in patients with non-muscle-invasive bladder cancer. / Shim, Ui Jae; Lee, Il Seok; Kang, Ho Won; Kim, Jayoung; Kim, Won Tae; Kim, Isaac; Ryu, Keun Ho; Choi, Yung Hyun; Moon, Sung Kwon; Kim, Yong June; Yun, Seok Joong; Lee, Sang Cheol; Kim, Wun Jae.

In: Korean Journal of Urology, Vol. 54, No. 9, 01.09.2013, p. 631-637.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Decreased DBC1 expression is associated with poor prognosis in patients with non-muscle-invasive bladder cancer

AU - Shim, Ui Jae

AU - Lee, Il Seok

AU - Kang, Ho Won

AU - Kim, Jayoung

AU - Kim, Won Tae

AU - Kim, Isaac

AU - Ryu, Keun Ho

AU - Choi, Yung Hyun

AU - Moon, Sung Kwon

AU - Kim, Yong June

AU - Yun, Seok Joong

AU - Lee, Sang Cheol

AU - Kim, Wun Jae

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Purpose: The deleted in bladder cancer 1 (DBC1) gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in bladder cancer (BC). It is suspected that it acts as a tumor suppressor gene, but its prognostic value remains unclear. The aim of the present study was to investigate the value of DBC1 as a prognostic marker in BC. Materials and Methods: The expression of DBC1 was determined by real-time polymer-ase chain reaction analysis in 344 patients with BC (220 non-muscle-invasive BC [NMIBC] and 124 muscle-invasive BC [MIBC]) and in 34 patients with normal bladder mucosa. The results were compared with clinicopathologic parameters, and the prognostic value of DBC1 was evaluated by Kaplan-Meier analysis and a multivariate Cox regression model. Results: DBC1 expression was significantly decreased in patients with MIBC compared with those diagnosed with NMIBC (p=0.010). Patients with aggressive tumor characteristics had lower DBC1 expression levels in NMIBC (each, p<0.05). By multivariate Cox regression analysis, low DBC1 expression was a predictor of progression to MIBC (hazard ratio, 7.104; p=0.013). Kaplan-Meier estimates revealed a significant difference in tumor recurrence, progression to MIBC, and cancer-specific survival depending on the level of DBC1 expression in NMIBC (log-rank test, each, p<0.05). Conclusions: The expression of DBC1 was associated with tumor aggressiveness, progression to MIBC, and survival in NMIBC. Our results suggest that DBC1 expression can be a useful prognostic marker for patients with NMIBC.

AB - Purpose: The deleted in bladder cancer 1 (DBC1) gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in bladder cancer (BC). It is suspected that it acts as a tumor suppressor gene, but its prognostic value remains unclear. The aim of the present study was to investigate the value of DBC1 as a prognostic marker in BC. Materials and Methods: The expression of DBC1 was determined by real-time polymer-ase chain reaction analysis in 344 patients with BC (220 non-muscle-invasive BC [NMIBC] and 124 muscle-invasive BC [MIBC]) and in 34 patients with normal bladder mucosa. The results were compared with clinicopathologic parameters, and the prognostic value of DBC1 was evaluated by Kaplan-Meier analysis and a multivariate Cox regression model. Results: DBC1 expression was significantly decreased in patients with MIBC compared with those diagnosed with NMIBC (p=0.010). Patients with aggressive tumor characteristics had lower DBC1 expression levels in NMIBC (each, p<0.05). By multivariate Cox regression analysis, low DBC1 expression was a predictor of progression to MIBC (hazard ratio, 7.104; p=0.013). Kaplan-Meier estimates revealed a significant difference in tumor recurrence, progression to MIBC, and cancer-specific survival depending on the level of DBC1 expression in NMIBC (log-rank test, each, p<0.05). Conclusions: The expression of DBC1 was associated with tumor aggressiveness, progression to MIBC, and survival in NMIBC. Our results suggest that DBC1 expression can be a useful prognostic marker for patients with NMIBC.

KW - Bladder cancer

KW - Human DBC1 protein

KW - Prognosis

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JO - Korean Journal of Urology

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