Decreased uptake of orotate in kidney tumors

M. A. Lea, M. R. Koch, H. P. Morris

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The uptake of isotope by three transplanted kidney tumors after i.p. injection of 3H labeled orotate was less than 5% of that in the host kidney cortex. A decrease of similar magnitude in the uptake into the acid soluble tissue fractions from the kidney tumors was observed with very low incorporation into RNA relative to the host kidney cortex. Total uptake of orotate 3H and incorporation into RNA were several fold higher in the normal kidney cortex than in the kidney medulla and for the kidney cortex both parameters were less in young than in old rats. The uptake of uracil 3H by two kidney tumors was approximately 40% of that in the kidney cortex of host rats. Although the uptake of orotate 3H in kidney cortex was greater than that for uracil 3H the reverse situation was observed with kidney tumors, indicating that renal neoplasia in the rat is accompanied by an altered pattern of uptake of these metabolites.

Original languageAmerican English
Pages (from-to)265-267
Number of pages3
JournalCancer biochemistry biophysics
Volume1
Issue number6
StatePublished - 1976

ASJC Scopus subject areas

  • Biophysics
  • Cancer Research

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