Dedifferentiated liposarcoma of thigh with chondrosarcomatous dedifferentiated component.

TY - JOUR

T1 - Dedifferentiated liposarcoma of thigh with chondrosarcomatous dedifferentiated component.

AU - Yoon, Richard S.

AU - Benevenia, Joseph

AU - Beebe, Kathleen S.

AU - Hameed, Meera

PY - 2010/11

Y1 - 2010/11

N2 - Liposarcomas are common soft-issue sarcomas arising predominantly in deep soft tissue and the retroperitoneum with varied mortality and recurrence rates, largely dependent on histologic type. Thought to arise de novo, liposarcomas typically are classified into 5 types based on strict morphologic characteristics: well-differentiated, dedifferentiated, myxoid, round cell, and pleomorphic. More specifically, dedifferentiated liposarcoma, a common type most prevalent in the retroperitoneum, often has 2 distinct components, a well-differentiated lipomatous component and a dedifferentiated nonlipomatous component composed of sarcomas, such as myxofibrosarcomas or other spindle-cell sarcomas. Morphology typically ranges from low- to high-grade components, most commonly exhibiting myxofibrosarcoma and malignant fibrous histiocytoma components. However, the case reported in this article is unique-the dedifferentiated component exhibited only chondrosarcomatous differentiation-and it is, to our knowledge, the first such case to be described.

AB - Liposarcomas are common soft-issue sarcomas arising predominantly in deep soft tissue and the retroperitoneum with varied mortality and recurrence rates, largely dependent on histologic type. Thought to arise de novo, liposarcomas typically are classified into 5 types based on strict morphologic characteristics: well-differentiated, dedifferentiated, myxoid, round cell, and pleomorphic. More specifically, dedifferentiated liposarcoma, a common type most prevalent in the retroperitoneum, often has 2 distinct components, a well-differentiated lipomatous component and a dedifferentiated nonlipomatous component composed of sarcomas, such as myxofibrosarcomas or other spindle-cell sarcomas. Morphology typically ranges from low- to high-grade components, most commonly exhibiting myxofibrosarcoma and malignant fibrous histiocytoma components. However, the case reported in this article is unique-the dedifferentiated component exhibited only chondrosarcomatous differentiation-and it is, to our knowledge, the first such case to be described.

UR - https://www.scopus.com/pages/publications/80053305688

UR - https://www.scopus.com/pages/publications/80053305688#tab=citedBy

M3 - Review article

C2 - 21623423

SN - 1078-4519

VL - 39

SP - E114-118

JO - American journal of orthopedics (Belle Mead, N.J.)

JF - American journal of orthopedics (Belle Mead, N.J.)

IS - 11

ER -