TY - JOUR
T1 - Deep brain stimulation for psychostimulant use disorders
AU - Swinford-Jackson, Sarah E.
AU - Pierce, R. Christopher
N1 - Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
PY - 2023
Y1 - 2023
N2 - Safe and effective therapeutics for psychostimulant use disorders remain elusive. Deep brain stimulation (DBS), which is FDA-approved for other indications, is a promising candidate for treating severe substance use disorders. We examine the clinical and preclinical evidence for DBS of the nucleus accumbens as a possible therapeutic option for cocaine and methamphetamine use disorders. Limitations of the literature to date, including the lack of females included in studies evaluating the efficacy of DBS, and new strategies to optimize brain stimulation approaches are also discussed.
AB - Safe and effective therapeutics for psychostimulant use disorders remain elusive. Deep brain stimulation (DBS), which is FDA-approved for other indications, is a promising candidate for treating severe substance use disorders. We examine the clinical and preclinical evidence for DBS of the nucleus accumbens as a possible therapeutic option for cocaine and methamphetamine use disorders. Limitations of the literature to date, including the lack of females included in studies evaluating the efficacy of DBS, and new strategies to optimize brain stimulation approaches are also discussed.
KW - Cocaine
KW - Deep brain stimulation
KW - Methamphetamine
KW - Nucleus accumbens
KW - Substance use disorders
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U2 - 10.1007/s00702-023-02706-6
DO - 10.1007/s00702-023-02706-6
M3 - Review article
C2 - 37823965
SN - 0300-9564
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
ER -