Design of net-charged abc-type collagen heterotrimers

Avanish S. Parmar, Sohail Zahid, Sandeep V. Belure, Robert Young, Nida Hasan, Vikas Nanda

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Net-negatively-charged heterospecific A:B:C collagen peptide heterotrimers were designed using an automated computational approach. The design algorithm considers both target stability and the energy gap between the target states and misfolded competing states. Structural characterization indicates the net-negative charge balance on the new designs enhances the specificity of the target state at the expense of its stability.

Original languageEnglish (US)
Pages (from-to)163-167
Number of pages5
JournalJournal of Structural Biology
Volume185
Issue number2
DOIs
StatePublished - Feb 2014

All Science Journal Classification (ASJC) codes

  • Structural Biology

Keywords

  • Collagen
  • Electrostatics
  • Protein design
  • Triple-helix

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