Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity

Jan Heeres, Marc R. De Jonge, Lucien M.H. Koymans, Frits F.D. Daeyaert, Maarten Vinkers, Koen J.A. Van Aken, Eddy Arnold, Kalyan Das, Amuri Kilonda, Georges J. Hoornaert, Frans Compernolle, Marek Cegla, Rasha A. Azzam, Koen Andries, Marie Pierre De Béthune, Hilde Azijn, Rudi Pauwels, Paul J. Lewi, Paul A.J. Janssen

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

A series of novel pyrazinones designed as non-nucleoside reverse transcriptase inhibitors (NNRTIs) was synthesized and their anti-HIV structure-activity relationship (SAR) was studied.

Original languageEnglish (US)
Pages (from-to)1910-1918
Number of pages9
JournalJournal of Medicinal Chemistry
Volume48
Issue number6
DOIs
StatePublished - Mar 24 2005

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Molecular Medicine

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