Designing polymers for the activation of, and selective resorption by, osteoclasts for bone regeneration

Stephanie L. Fung, Daniel Martin, Anisha Mahat, Prakhar Mishra, Jarrod Cohen, E. Thomas Pashuck, Yong Mao, Prabhas V. Moghe, Antonio Merolli, Joachim Kohn

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: The majority of bone regeneration efforts focus on the production of bone by osteoblasts and osteocytes, while largely overlooking the other cell types in the wound environment. The overall goal of this project is to re-establish bone turnover by designing a biomaterial that specifically supports the activation of, and degradation by, osteoclasts. Peptides that are cleaved specifically by proteases are often used to crosslink hydrogels to promote cell-specific migration and to tether drugs to surfaces for improving targeting, but their use as sensitive linkages in a polymer backbone is largely unexplored. In this study, a two-pronged approach to designing biomaterials for osteoclast activation and resorption is explored. The first is the polymerization of a tyrosine-derived polymer with a cathepsin K-sensitive peptide in the backbone, which was designed to degrade specifically in the presence of osteoclasts. The second is the use of E1001(1k), a tyrosine polycarbonate that has shown promising results for bone regeneration in the past1. The ability of a material to support osteoclast activation and degradation is critical for re-establishing bone turnover and vascularization of the regenerated tissue, and it is advantageous to employ the cells physiologically responsible for resorption as a means of resorbing the supporting polymer during the regeneration process.

Original languageAmerican English
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages434
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/TerritoryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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