Development and teratogenic effects of methyl mercury on Drosophila

K. Voss, W. Chang, Kenneth Reuhl

Research output: Contribution to journalArticle

Abstract

Eggs from Drosophila melanogaster were transferred to food media containing 0.01, 0.10, 0.25, 0.50, 0.75 and 1.00 ppm methyl mercuric chloride (MMC). At 0.1 to 0.50 ppm MMC an increase in pupation rate occurred. At higher concentrations (0.75 to 1.00 ppm) a decreased pupation rate was seen. An increased developmental time was also noted for larvae exposed to more than 0.50 ppm MMC. At higher concentrations (0.10 ppm to 1.00 ppm), a marked decrease in the percentage of wild type flies occurred, indicating an increase in mutation rate at these dose levels. Mutant flies displayed 3 anomalies: loss of wild type body color; elongation of the abdomen, giving it a cylindrical appearance; and severely wrinkled and shortened wings. Both sexes were affected. Mutants appeared weakened and died within hours of emergence from pupal casings. A shift in the sex ratios of population exposed to various amounts of MMC also occurred. When all the hatched flies were considered, the sex ratio favored females. However, if only wild type flies were considered, the sex ratios favored males. These observations indicated that there was a difference in the toxicity of MMC towards the developing male and female Drosophila.

Original languageEnglish (US)
JournalAmerican Journal of Pathology
Volume78
Issue number1
StatePublished - Jan 1 1975
Externally publishedYes

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Methyl Chloride
Mercuric Chloride
Mercury
Drosophila
Diptera
Sex Ratio
Somatotypes
Mutation Rate
Drosophila melanogaster
Abdomen
Eggs
Larva
Color
Food
Population

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

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Development and teratogenic effects of methyl mercury on Drosophila. / Voss, K.; Chang, W.; Reuhl, Kenneth.

In: American Journal of Pathology, Vol. 78, No. 1, 01.01.1975.

Research output: Contribution to journalArticle

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