Development and validation of a symptom-focused quality of life questionnaire (koquss-40) for gastric cancer patients after gastrectomy

TY - JOUR

T1 - Development and validation of a symptom-focused quality of life questionnaire (koquss-40) for gastric cancer patients after gastrectomy

AU - Eom, Bang Wool

AU - Lee, Joongyub

AU - Lee, In Seob

AU - Son, Young Gil

AU - Ryu, Keun Won

AU - Kim, Sung Geun

AU - Kim, Hyoung Il

AU - Kim, Young Woo

AU - Kong, Seong Ho

AU - Kwon, Oh Kyoung

AU - Park, Ji Ho

AU - An, Ji Yeong

AU - Kim, Chang Hyun

AU - Suh, Byoung Jo

AU - Yoon, Hong Man

AU - Son, Myoung Won

AU - Park, Ji Yeon

AU - Park, Jong Min

AU - Jeong, Sang Ho

AU - Yoo, Moon Won

AU - Song, Geum Jong

AU - Yang, Han Kwang

AU - Suh, Yun Suhk

AU - Park, Ki Bum

AU - Ahn, Sang Hoon

AU - Shin, Dong Woo

AU - Jee, Ye Seob

AU - Ahn, Hye Seong

AU - Lee, Sol

AU - Min, Jae Seok

AU - In, Haejin

AU - Kim, Ahyoung

AU - Hur, Hoon

AU - Lee, Hyuk Joon

N1 - Publisher Copyright: © 2021 Korean Cancer Association. All rights reserved.

PY - 2021

Y1 - 2021

N2 - Purpose Patients who have undergone gastrectomy have unique symptoms that are not appropriately assessed using currently available tools. This study developed and validated a symptom-focused quality of life (QoL) questionnaire for patients who have received gastrectomy for gastric cancer. Materials and Methods Based on a literature review, patient interviews, and expert consultation by the KOrean QUality of life in Stomach cancer patients Study group (KOQUSS), the initial item pool was developed. Two large-scale developmental studies were then sequentially conducted for exploratory factor analyses for content validity and item reduction. The final item pool was validated in a separate cohort of patients and assessed for internal consistency, test-retest reliability, construct validity, and clinical validity. Results The initial questionnaire consisted of 46-items in 12 domains. Data from 465 patients at 11 institutions, followed by 499 patients at 13 institutions, were used to conduct item reduction and exploratory factor analyses. The final questionnaire (KOQUSS-40) comprised 40 items within 11 domains. Validation of KOQUSS-40 was conducted on 413 patients from 12 hospitals. KOQUSS-40 was found to have good model fit. The mean summary score of the KOQUSS-40 was correlated with the EORTC QLQ-C30 and STO22 (correlation coefficients, 0.821 and 0.778, respectively). The KOQUSS-40 score was also correlated with clinical factors, and had acceptable internal consistency (> 0.7). Test-retest reliability was greater than 0.8. Conclusion The KOQUSS-40 can be used to assess QoL of gastric cancer patients after gastrectomy and allows for a robust comparison of surgical techniques in clinical trials.

AB - Purpose Patients who have undergone gastrectomy have unique symptoms that are not appropriately assessed using currently available tools. This study developed and validated a symptom-focused quality of life (QoL) questionnaire for patients who have received gastrectomy for gastric cancer. Materials and Methods Based on a literature review, patient interviews, and expert consultation by the KOrean QUality of life in Stomach cancer patients Study group (KOQUSS), the initial item pool was developed. Two large-scale developmental studies were then sequentially conducted for exploratory factor analyses for content validity and item reduction. The final item pool was validated in a separate cohort of patients and assessed for internal consistency, test-retest reliability, construct validity, and clinical validity. Results The initial questionnaire consisted of 46-items in 12 domains. Data from 465 patients at 11 institutions, followed by 499 patients at 13 institutions, were used to conduct item reduction and exploratory factor analyses. The final questionnaire (KOQUSS-40) comprised 40 items within 11 domains. Validation of KOQUSS-40 was conducted on 413 patients from 12 hospitals. KOQUSS-40 was found to have good model fit. The mean summary score of the KOQUSS-40 was correlated with the EORTC QLQ-C30 and STO22 (correlation coefficients, 0.821 and 0.778, respectively). The KOQUSS-40 score was also correlated with clinical factors, and had acceptable internal consistency (> 0.7). Test-retest reliability was greater than 0.8. Conclusion The KOQUSS-40 can be used to assess QoL of gastric cancer patients after gastrectomy and allows for a robust comparison of surgical techniques in clinical trials.

KW - Quality of life

KW - Stomach neoplasms

KW - Surveys and questionnaires

KW - Validation study

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U2 - 10.20538/1682-0363-2021-2-233-238

DO - 10.20538/1682-0363-2021-2-233-238

M3 - Review article

C2 - 33421981

SN - 1598-2998

VL - 53

SP - 763

EP - 772

JO - Cancer Research and Treatment

JF - Cancer Research and Treatment

IS - 3

ER -