Diastereoselective synthesis of substituted diaziridines from simple ketones and aldehydes

Alexander W. Beebe; Emma F. Dohmeier; Gustavo Moura-Letts

doi:https://doi.org/10.1039/c5cc04813c

Diastereoselective synthesis of substituted diaziridines from simple ketones and aldehydes

Alexander W. Beebe, Emma F. Dohmeier, Gustavo Moura-Letts

Chemistry

Rowan University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Diastereopure substituted diaziridines from simple ketones, aldehydes and amines are here reported. These important chemical scaffolds are obtained in the presence of a weak inorganic base and hydroxylamine O-sulfonic acid (HOSA). This method introduces three stereocenters in one step to provide a wide variety of substituted diaziridines with high yields and diastereoselectivities.

Original language	American English
Pages (from-to)	13511-13514
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	70
DOIs	https://doi.org/10.1039/c5cc04813c
State	Published - Jul 20 2015

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "Diastereopure substituted diaziridines from simple ketones, aldehydes and amines are here reported. These important chemical scaffolds are obtained in the presence of a weak inorganic base and hydroxylamine O-sulfonic acid (HOSA). This method introduces three stereocenters in one step to provide a wide variety of substituted diaziridines with high yields and diastereoselectivities.",

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AU - Beebe, Alexander W.

AU - Dohmeier, Emma F.

AU - Moura-Letts, Gustavo

PY - 2015/7/20

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N2 - Diastereopure substituted diaziridines from simple ketones, aldehydes and amines are here reported. These important chemical scaffolds are obtained in the presence of a weak inorganic base and hydroxylamine O-sulfonic acid (HOSA). This method introduces three stereocenters in one step to provide a wide variety of substituted diaziridines with high yields and diastereoselectivities.

AB - Diastereopure substituted diaziridines from simple ketones, aldehydes and amines are here reported. These important chemical scaffolds are obtained in the presence of a weak inorganic base and hydroxylamine O-sulfonic acid (HOSA). This method introduces three stereocenters in one step to provide a wide variety of substituted diaziridines with high yields and diastereoselectivities.

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Diastereoselective synthesis of substituted diaziridines from simple ketones and aldehydes

Abstract

ASJC Scopus subject areas

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