Dibutyryl cAMP stimulates analgesia in rats bearing a ventricular adrenal medulla transplant

María T. Pacheco-Cano, Fernando García-Hernández, Marcia Hiriart, Barry R. Komisaruk, René Drucker-Colín

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

In the present study, a significant increase in pain threshold (current to elicit vocalization to tail shock) was found 15 and 60 min after injection of dibutyryl cyclic AMP (db cAMP) (30 μg) into the lateral ventricle in rats bearing a transplant of fetal adrenal medulla (AM). By contrast, no effect on pain threshold was observed in rats bearing an AM transplant but receiving no db cAMP, or in rats receiving db cAMP but not bearing an AM transplant. In primary cultures of rat fetal chromaffin cells, db cAMP increased the number of neuron-like cells that showed both vasoactive intestinal polypeptide (VIP)- and tyrosine hydroxylase (TH)-like immunoreactivity. These findings indicate that db cAMP exerts a pharmacological modulation of the functional activity (i.e. elevation in pain thresholds) of fetal adrenal AM transplants, and induces phenotypic changes in cultured chromaffin cells with expression of a peptide that elevates pain threshold.

Original languageEnglish (US)
Pages (from-to)290-293
Number of pages4
JournalBrain research
Volume531
Issue number1-2
DOIs
StatePublished - Oct 29 1990

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • Adrenal medulla
  • Analgesia
  • Dibutyryl cAMP
  • Striatum
  • Transplant
  • Vasoactive intestinal polypeptide

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