Diet Supplementation with Allicin Protects against Alcoholic Fatty Liver Disease in Mice by Improving Anti-inflammation and Antioxidative Functions

Suraphan Panyod, Wei Kai Wu, Chi Tang Ho, Kuan Hung Lu, Chun Ting Liu, Yung Lin Chu, Yi Syuan Lai, Wei Cheng Chen, Yu En Lin, Shih Hang Lin, Lee Yan Sheen

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

This study investigated the liver-protective effects of allicin, an active compound in fresh garlic, against alcoholic fatty liver disease (AFLD) and liver inflammation. Its effects were investigated in an AFLD model in male C57BL/6 mice, which were fed Lieber-DeCarli liquid diet containing ethanol. Allicin (5 and 20 mg/kg bw/day) was orally administered daily in the AFLD mice for 4 weeks. The results indicate that allicin promotes hepatoprotection by significantly reducing aspartate transaminase (AST) and alanine transaminase (ALT) levels (p < 0.05) in the plasma, which are key indicators of liver damage. Allicin reduced fat accumulation, increased glutathione and catalase levels, and decreased microsomal protein cytochrome P450 2E1 (CYP2E1) expression (p < 0.05) in the livers of the AFLD mice. Furthermore, allicin supplementation significantly decreased the levels of proinflammatory tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 and suppressed the expression of sterol regulatory element-binding protein-1 (SREBP-1) (p < 0.05). Additionally, it improved the hepatic alcohol dehydrogenase (ADH) activity (p < 0.05). Collectively, these findings demonstrate that allicin attenuates liver oxidative stress and inflammation.

Original languageEnglish (US)
Pages (from-to)7104-7113
Number of pages10
JournalJournal of agricultural and food chemistry
Volume64
Issue number38
DOIs
StatePublished - Sep 28 2016

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

Keywords

  • alcoholic fatty liver disease
  • allicin
  • hepatic steatosis
  • liver antioxidant
  • liver inflammation

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