Dilated cardiomyopathy in children with acquired immunodeficiency syndrome:. A pathologic study of five cases

V. V. Joshi, C. Gadol, E. Connor, J. M. Oleske, J. Mendelson, J. Marin-Garcia

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Abstract

Clinicopathologic features with special reference to the heart are presented in five fatal cases of acquired immunodeficiency syndrome (AIDS) in children. Three children showed clinical evidence of cardiovascular compromise or congestive heart failure. Autopsy was performed in all cases. The enlarged heart showed biventricular dilatation with grossly unremarkable valves and coronary arteries and absence of mural thrombi. Microscopic examination of the heart revealed primarily myopathic abnormalities with hypertrophy of the myocardium and only rare foci of sparse inflammatory infiltrate. The pathogenesis of dilated cardiomyopathy in these children with AIDS is not known. Infection, immunologic factors anemia, deficiency of nutritional factor(s), and longer survival may be related to the pathogenesis. Pediatricians should be alert to the possibility of cardiac involvement in pediatric.

Original languageEnglish (US)
Pages (from-to)69-73
Number of pages5
JournalHuman Pathology
Volume19
Issue number1
DOIs
StatePublished - Jan 1988

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Keywords

  • AIDS
  • anemia
  • autopsy
  • children
  • dilated cardiomyopathy
  • heart

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