Disparate cell types use a shared complex of PDZ proteins for polarized protein localization

Christopher Rongo

doi:10.1016/S1359-6101(01)00011-9

Disparate cell types use a shared complex of PDZ proteins for polarized protein localization

Christopher Rongo

Rutgers, The State University

Research output: Contribution to journal › Short survey › peer-review

13 Scopus citations

Abstract

Based on their morphology and function, epithelial cells and neurons appear to have very little in common; however, growing evidence indicates that these two disparate cell types share an underlying polarization pathway responsible for sorting proteins to specific subcellular sites. An evolutionarily conserved complex of PDZ domain-containing proteins thought to be responsible for polarized protein localization has been identified from both brain and epithelial tissue, both from mammals and from the nematode C. elegans. Some of the most recent data on PDZ proteins and the proteins with which they interact are summarized. In particular, some of the more recently proposed models for their function in cells, and the in vivo and in vitro data that support these models are focussed upon.

Original language	American English
Pages (from-to)	349-359
Number of pages	11
Journal	Cytokine and Growth Factor Reviews
Volume	12
Issue number	4
DOIs	https://doi.org/10.1016/S1359-6101(01)00011-9
State	Published - 2001

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Immunology
General Biochemistry, Genetics and Molecular Biology

Keywords

Cell polarity
MAGUK proteins
PDZ proteins
Synapse formation

Access to Document

10.1016/S1359-6101(01)00011-9

Cite this

@article{1d151b7113834e5d81d4f82f3f15b62f,

title = "Disparate cell types use a shared complex of PDZ proteins for polarized protein localization",

abstract = "Based on their morphology and function, epithelial cells and neurons appear to have very little in common; however, growing evidence indicates that these two disparate cell types share an underlying polarization pathway responsible for sorting proteins to specific subcellular sites. An evolutionarily conserved complex of PDZ domain-containing proteins thought to be responsible for polarized protein localization has been identified from both brain and epithelial tissue, both from mammals and from the nematode C. elegans. Some of the most recent data on PDZ proteins and the proteins with which they interact are summarized. In particular, some of the more recently proposed models for their function in cells, and the in vivo and in vitro data that support these models are focussed upon.",

keywords = "Cell polarity, MAGUK proteins, PDZ proteins, Synapse formation",

author = "Christopher Rongo",

year = "2001",

doi = "10.1016/S1359-6101(01)00011-9",

language = "American English",

volume = "12",

pages = "349--359",

journal = "Cytokine and Growth Factor Reviews",

issn = "1359-6101",

publisher = "Elsevier Ltd",

number = "4",

}

TY - JOUR

T1 - Disparate cell types use a shared complex of PDZ proteins for polarized protein localization

AU - Rongo, Christopher

PY - 2001

Y1 - 2001

N2 - Based on their morphology and function, epithelial cells and neurons appear to have very little in common; however, growing evidence indicates that these two disparate cell types share an underlying polarization pathway responsible for sorting proteins to specific subcellular sites. An evolutionarily conserved complex of PDZ domain-containing proteins thought to be responsible for polarized protein localization has been identified from both brain and epithelial tissue, both from mammals and from the nematode C. elegans. Some of the most recent data on PDZ proteins and the proteins with which they interact are summarized. In particular, some of the more recently proposed models for their function in cells, and the in vivo and in vitro data that support these models are focussed upon.

AB - Based on their morphology and function, epithelial cells and neurons appear to have very little in common; however, growing evidence indicates that these two disparate cell types share an underlying polarization pathway responsible for sorting proteins to specific subcellular sites. An evolutionarily conserved complex of PDZ domain-containing proteins thought to be responsible for polarized protein localization has been identified from both brain and epithelial tissue, both from mammals and from the nematode C. elegans. Some of the most recent data on PDZ proteins and the proteins with which they interact are summarized. In particular, some of the more recently proposed models for their function in cells, and the in vivo and in vitro data that support these models are focussed upon.

KW - Cell polarity

KW - MAGUK proteins

KW - PDZ proteins

KW - Synapse formation

UR - http://www.scopus.com/inward/record.url?scp=0034854112&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034854112&partnerID=8YFLogxK

U2 - 10.1016/S1359-6101(01)00011-9

DO - 10.1016/S1359-6101(01)00011-9

M3 - Short survey

C2 - 11544104

SN - 1359-6101

VL - 12

SP - 349

EP - 359

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

IS - 4

ER -

Disparate cell types use a shared complex of PDZ proteins for polarized protein localization

Abstract

ASJC Scopus subject areas

Keywords

Access to Document

Other files and links

Fingerprint

Cite this