DNA aptamer-mediated cell targeting

Xiangling Xiong, Haipeng Liu, Zilong Zhao, Meghan B. Altman, Dalia Lopez-Colon, Chaoyong James Yang, Lung Ji Chang, Chen Liu, Weihong Tan

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

An apt modification: A simple and effective way to modify the cell surface with target-specific ligands, such as DNA aptamers, while minimizing the effects on the modified cells has been developed. After incubating with lipo-aptamer probes, immune cells (red, see scheme) recognize and kill cancer cells (blue) in the cell mixture.

Original languageEnglish (US)
Pages (from-to)1472-1476
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number5
DOIs
StatePublished - Jan 28 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Catalysis

Keywords

  • DNA
  • aptamers
  • cell modification
  • cell recognition
  • cell-based immunotherapy

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