Dosimetry modeling of inhaled particles

M. Lazaridis, Panagiotis Georgopoulos, O. Hov, C. Guerreiro

Research output: Contribution to conferencePaper

Abstract

A one dimensional model for describing the transport and fate of inhaled particles and gases in the human respiratory tract has been developed. The architecture of the human lung is described using the Weibel's model with regularized dichotomy. The Aerosol General Dynamic Equation is solved numerically during inhalation using a discrete-nodal point method for describing the particle size distribution. In the model the mechanisms of nucleation, condensation, coagulation, convection and deposition of gases and particles and a module for considering gas phase reactions have been included. Boundary layer effects are incorporated in the model by introducing appropriate dimensionless numbers (Nusslet, Sherwood) in the estimation of the thickness of the corresponding boundary layer. The model predicts the evolution of the size distribution and composition of inhaled particles and their deposition characteristics for each generation of the human airways. An application to study the deposition profile of inhaled particles under different experimental studies has been performed. The results of the model are in qualitative agreement with the Tracheobronchial and Alveolar deposition data.

Original languageEnglish (US)
Pages939-946
Number of pages8
StatePublished - Dec 1 1998
EventProceedings of the 1998 6th International Conference on Air Pollution - Genoa, Italy
Duration: Sep 28 1998Sep 30 1998

Other

OtherProceedings of the 1998 6th International Conference on Air Pollution
CityGenoa, Italy
Period9/28/989/30/98

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Dosimetry
Boundary layers
Gases
Coagulation
Particle size analysis
Aerosols
Condensation
Nucleation
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Pollution

Cite this

Lazaridis, M., Georgopoulos, P., Hov, O., & Guerreiro, C. (1998). Dosimetry modeling of inhaled particles. 939-946. Paper presented at Proceedings of the 1998 6th International Conference on Air Pollution, Genoa, Italy, .
Lazaridis, M. ; Georgopoulos, Panagiotis ; Hov, O. ; Guerreiro, C. / Dosimetry modeling of inhaled particles. Paper presented at Proceedings of the 1998 6th International Conference on Air Pollution, Genoa, Italy, .8 p.
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Lazaridis, M, Georgopoulos, P, Hov, O & Guerreiro, C 1998, 'Dosimetry modeling of inhaled particles' Paper presented at Proceedings of the 1998 6th International Conference on Air Pollution, Genoa, Italy, 9/28/98 - 9/30/98, pp. 939-946.

Dosimetry modeling of inhaled particles. / Lazaridis, M.; Georgopoulos, Panagiotis; Hov, O.; Guerreiro, C.

1998. 939-946 Paper presented at Proceedings of the 1998 6th International Conference on Air Pollution, Genoa, Italy, .

Research output: Contribution to conferencePaper

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Lazaridis M, Georgopoulos P, Hov O, Guerreiro C. Dosimetry modeling of inhaled particles. 1998. Paper presented at Proceedings of the 1998 6th International Conference on Air Pollution, Genoa, Italy, .