Abstract
Nightmares and flashbacks are common debilitating symptoms of posttraumatic stress disorder (PTSD) that can disrupt daily functioning. Prazosin, an alpha-1 adrenergic antagonist, has been commonly used off-label for the treatment of these intrusion symptoms, although its short half-life makes it so that often multiple doses are needed. Doxazosin, another alpha-1 antagonist, is starting to be investigated in the treatment of PTSD-related nightmares due to its lesser side effect profile and longer half-life. In our case series, we present three cases of patients with PTSD-related nightmares who were successfully treated with doxazosin following a relapse of symptoms after discontinuation of prazosin for various reasons. The success of doxazosin immediate release for PTSD-related nightmares warrants further studies into its efficacy and use as an alternative treatment to prazosin.
| Original language | English (US) |
|---|---|
| Article number | 6452923 |
| Journal | Case Reports in Psychiatry |
| Volume | 2024 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2024 |
| Externally published | Yes |
ASJC Scopus subject areas
- Psychiatry and Mental health
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