Dynamic Perspectives on the Search for a Universal Influenza Vaccine

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

A universal influenza vaccine (UIV) could considerably alleviate the public health burden of both seasonal and pandemic influenza. Although significant progress has been achieved in clarifying basic immunology and virology relating to UIV, several important questions relating to the dynamics of infection, immunity, and pathogen evolution remain unsolved. In this study, we review these gaps, which span integrative levels, from cellular to global and timescales from molecular events to decades. We argue that they can be best addressed by a tight integration of empirical (laboratory, epidemiological) research and theory and suggest fruitful areas for this synthesis. In particular, quantifying natural and vaccinal limitations on viral transmission are central to this effort.

Original languageEnglish (US)
Pages (from-to)S46-S56
JournalJournal of Infectious Diseases
Volume219
DOIs
StatePublished - Apr 8 2019

Fingerprint

Influenza Vaccines
Virology
Pandemics
Allergy and Immunology
Human Influenza
Immunity
Public Health
Infection
Research

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Immunology and Allergy

Keywords

  • Influenza vaccination
  • Shedding-transmission relationship
  • Viral eco-evolutionary dynamics

Cite this

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title = "Dynamic Perspectives on the Search for a Universal Influenza Vaccine",
abstract = "A universal influenza vaccine (UIV) could considerably alleviate the public health burden of both seasonal and pandemic influenza. Although significant progress has been achieved in clarifying basic immunology and virology relating to UIV, several important questions relating to the dynamics of infection, immunity, and pathogen evolution remain unsolved. In this study, we review these gaps, which span integrative levels, from cellular to global and timescales from molecular events to decades. We argue that they can be best addressed by a tight integration of empirical (laboratory, epidemiological) research and theory and suggest fruitful areas for this synthesis. In particular, quantifying natural and vaccinal limitations on viral transmission are central to this effort.",
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Dynamic Perspectives on the Search for a Universal Influenza Vaccine. / Grenfell, Bryan T.

In: Journal of Infectious Diseases, Vol. 219, 08.04.2019, p. S46-S56.

Research output: Contribution to journalReview article

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AB - A universal influenza vaccine (UIV) could considerably alleviate the public health burden of both seasonal and pandemic influenza. Although significant progress has been achieved in clarifying basic immunology and virology relating to UIV, several important questions relating to the dynamics of infection, immunity, and pathogen evolution remain unsolved. In this study, we review these gaps, which span integrative levels, from cellular to global and timescales from molecular events to decades. We argue that they can be best addressed by a tight integration of empirical (laboratory, epidemiological) research and theory and suggest fruitful areas for this synthesis. In particular, quantifying natural and vaccinal limitations on viral transmission are central to this effort.

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