Abstract
We determined the microbicidal activities of antibacterials against nonreplicating Mycobacterium smegmatis grown in a starvation- based Loebel model for persistence. Whereas most drugs lost their activity, fluoroquinolones retained lethal potency. Doseresponse characterizations showed a paradoxical more-drug-kills-less Eagle effect. Pretreatment of cultures with chloramphenicol blocked the lethal action of the gyrase inhibitors. These results suggest that fluoroquinolones at low concentrations trigger a protein synthesis-dependent cell death pathway and shut off this suicide pathway at elevated concentrations.
| Original language | English |
|---|---|
| Pages (from-to) | 7786-7789 |
| Number of pages | 4 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 59 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2015 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
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