Early Events Triggering the Initiation of a Type 2 Immune Response

Darine W. El-Naccache; György Haskó; William C. Gause

doi:https://doi.org/10.1016/j.it.2020.11.006

Early Events Triggering the Initiation of a Type 2 Immune Response

Darine W. El-Naccache, György Haskó, William C. Gause

Rutgers, The State University

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Type 2 immune responses are typically associated with protection against helminth infections and also with harmful inflammation in response to allergens. Recent advances have revealed that type 2 immunity also contributes to sterile inflammation, cancer, and microbial infections. However, the early events that initiate type 2 immune responses remain poorly defined. New insights reveal major contributions from danger-associated molecular patterns (DAMPs) in the initiation of type 2 immune responses. In this review, we examine the molecules released by the host and pathogens and the role they play in mediating the initiation of mammalian innate type 2 immune responses under a variety of conditions.

Original language	English (US)
Pages (from-to)	151-164
Number of pages	14
Journal	Trends in Immunology
Volume	42
Issue number	2
DOIs	https://doi.org/10.1016/j.it.2020.11.006
State	Published - Feb 2021

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Keywords

DAMPs
allergens
cancer
helminths
sterile inflammation

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https://doi.org/10.1016/j.it.2020.11.006

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title = "Early Events Triggering the Initiation of a Type 2 Immune Response",

abstract = "Type 2 immune responses are typically associated with protection against helminth infections and also with harmful inflammation in response to allergens. Recent advances have revealed that type 2 immunity also contributes to sterile inflammation, cancer, and microbial infections. However, the early events that initiate type 2 immune responses remain poorly defined. New insights reveal major contributions from danger-associated molecular patterns (DAMPs) in the initiation of type 2 immune responses. In this review, we examine the molecules released by the host and pathogens and the role they play in mediating the initiation of mammalian innate type 2 immune responses under a variety of conditions.",

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author = "El-Naccache, {Darine W.} and Gy{\"o}rgy Hask{\'o} and Gause, {William C.}",

note = "Funding Information: National Institutes of Health (NIH) grants R01GM066189 (G.H.) and R01DK113790 (W.C.G. and G.H.), R01DK113790 (W.C.G), R01AI131634 (W.C.G), and T32AI125185 to D.W.E. G.H. owns stock in Purine Pharmaceuticals, Inc. and has patents related to purinergic signaling in sepsis. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

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doi = "https://doi.org/10.1016/j.it.2020.11.006",

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AU - El-Naccache, Darine W.

AU - Haskó, György

AU - Gause, William C.

N1 - Funding Information: National Institutes of Health (NIH) grants R01GM066189 (G.H.) and R01DK113790 (W.C.G. and G.H.), R01DK113790 (W.C.G), R01AI131634 (W.C.G), and T32AI125185 to D.W.E. G.H. owns stock in Purine Pharmaceuticals, Inc. and has patents related to purinergic signaling in sepsis. Publisher Copyright: © 2020 Elsevier Ltd

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N2 - Type 2 immune responses are typically associated with protection against helminth infections and also with harmful inflammation in response to allergens. Recent advances have revealed that type 2 immunity also contributes to sterile inflammation, cancer, and microbial infections. However, the early events that initiate type 2 immune responses remain poorly defined. New insights reveal major contributions from danger-associated molecular patterns (DAMPs) in the initiation of type 2 immune responses. In this review, we examine the molecules released by the host and pathogens and the role they play in mediating the initiation of mammalian innate type 2 immune responses under a variety of conditions.

AB - Type 2 immune responses are typically associated with protection against helminth infections and also with harmful inflammation in response to allergens. Recent advances have revealed that type 2 immunity also contributes to sterile inflammation, cancer, and microbial infections. However, the early events that initiate type 2 immune responses remain poorly defined. New insights reveal major contributions from danger-associated molecular patterns (DAMPs) in the initiation of type 2 immune responses. In this review, we examine the molecules released by the host and pathogens and the role they play in mediating the initiation of mammalian innate type 2 immune responses under a variety of conditions.

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KW - cancer

KW - helminths

KW - sterile inflammation

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Early Events Triggering the Initiation of a Type 2 Immune Response

Abstract

ASJC Scopus subject areas

Keywords

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