Echinocandin failure case due to a previously unreported fks1 mutation in candida krusei

Rasmus Hare Jensen, Ulrik Stenz Justesen, Annika Rewes, David S. Perlin, Maiken Cavling Arendrup

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Echinocandins are the preferred therapy for invasive infections due to Candida krusei. We present here a case of clinical failure involving C. krusei with a characteristic FKS1 hot spot mutation not previously reported in C. krusei that was isolated after 14 days of treatment. Anidulafungin MICs were elevated by≥5 dilution steps above the clinical breakpoint but by only 1 step for a Candida albicans isolate harboring the corresponding mutation, suggesting a notable species-specific difference in the MIC increase conferred by this mutation.

Original languageEnglish (US)
Pages (from-to)3550-3552
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume58
Issue number6
DOIs
StatePublished - Jun 2014

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology

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