Effect of antihypertensive therapy on renal artery structure in type 2 diabetic rats with hypertension

Alluru Reddi, Venkata R. Nimmagadda, Rohit Arora

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We have previously demonstrated that antihypertensive treatment with doxazosin (DZN), an α-adrenergic blocker, and lisinopril (LIS), an ACE inhibitor, reverse glomerular sclerosis in corpulent spontaneously hypertensive rats with type 2 diabetes. In this study, we examined the effects of the above-mentioned antihypertensive drugs alone and in combination on the structure of interlobular and arcuate arteries in these rats. Both male and female rats aged 6 months were treated with antihypertensive drugs for 16 weeks. Various structural parameters were evaluated by light microscopy, with the use of digital image analysis, in kidney sections stained with periodic acid-Schiff. Systolic blood pressure was significantly lower in treated than in untreated rats. Untreated diabetic rats had a significantly higher media/lumen ratio (smaller luminal diameter) of both arteries compared with the ratio in treated rats (for interlobular artery, 0.72+0.06 [no treatment], 0.49±0.03 [DZN treatment], 0.54±0.06 [LIS treatment], and 0.52±0.04 [combination therapy], P<0.05 to <0.001 for no treatment versus treatment; for arcuate artery, 0.66±0.11 [no treatment], 0.40±0.02 [DZN treatment], 0.39±0.04 [LIS treatment], and 0.40±0.03 [combination therapy], P<0.05 for no treatment versus treatment). Antihypertensive treatment caused significant increases in total arterial cross-sectional area, internal and external diameters, luminal and medial cross-sectional area, and medial thickness in both interlobular and arcuate arteries. The improvement in arterial structure after antihypertensive treatment was due to remodeling and growth of the vessels. Both DZN and LIS were equally efficacious, and combination therapy had no additive or synergistic effect.

Original languageEnglish (US)
Pages (from-to)1273-1278
Number of pages6
JournalHypertension
Volume37
Issue number5
DOIs
StatePublished - Jan 1 2001

Fingerprint

Doxazosin
Lisinopril
Renal Artery
Antihypertensive Agents
Arteries
Hypertension
Blood Pressure
Therapeutics
Periodic Acid
Adrenergic Antagonists
Sclerosis
Inbred SHR Rats
Angiotensin-Converting Enzyme Inhibitors
Type 2 Diabetes Mellitus
Microscopy
Kidney
Light
Growth

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Keywords

  • Adrenergic receptor blockers
  • Angiotensin-converting enzyme inhibitors
  • Arteries
  • Diabetes mellitus
  • Hypertension, experimental
  • Kidney
  • Rats, inbred SHR

Cite this

Reddi, Alluru ; Nimmagadda, Venkata R. ; Arora, Rohit. / Effect of antihypertensive therapy on renal artery structure in type 2 diabetic rats with hypertension. In: Hypertension. 2001 ; Vol. 37, No. 5. pp. 1273-1278.
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abstract = "We have previously demonstrated that antihypertensive treatment with doxazosin (DZN), an α-adrenergic blocker, and lisinopril (LIS), an ACE inhibitor, reverse glomerular sclerosis in corpulent spontaneously hypertensive rats with type 2 diabetes. In this study, we examined the effects of the above-mentioned antihypertensive drugs alone and in combination on the structure of interlobular and arcuate arteries in these rats. Both male and female rats aged 6 months were treated with antihypertensive drugs for 16 weeks. Various structural parameters were evaluated by light microscopy, with the use of digital image analysis, in kidney sections stained with periodic acid-Schiff. Systolic blood pressure was significantly lower in treated than in untreated rats. Untreated diabetic rats had a significantly higher media/lumen ratio (smaller luminal diameter) of both arteries compared with the ratio in treated rats (for interlobular artery, 0.72+0.06 [no treatment], 0.49±0.03 [DZN treatment], 0.54±0.06 [LIS treatment], and 0.52±0.04 [combination therapy], P<0.05 to <0.001 for no treatment versus treatment; for arcuate artery, 0.66±0.11 [no treatment], 0.40±0.02 [DZN treatment], 0.39±0.04 [LIS treatment], and 0.40±0.03 [combination therapy], P<0.05 for no treatment versus treatment). Antihypertensive treatment caused significant increases in total arterial cross-sectional area, internal and external diameters, luminal and medial cross-sectional area, and medial thickness in both interlobular and arcuate arteries. The improvement in arterial structure after antihypertensive treatment was due to remodeling and growth of the vessels. Both DZN and LIS were equally efficacious, and combination therapy had no additive or synergistic effect.",
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Effect of antihypertensive therapy on renal artery structure in type 2 diabetic rats with hypertension. / Reddi, Alluru; Nimmagadda, Venkata R.; Arora, Rohit.

In: Hypertension, Vol. 37, No. 5, 01.01.2001, p. 1273-1278.

Research output: Contribution to journalArticle

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T1 - Effect of antihypertensive therapy on renal artery structure in type 2 diabetic rats with hypertension

AU - Reddi, Alluru

AU - Nimmagadda, Venkata R.

AU - Arora, Rohit

PY - 2001/1/1

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AB - We have previously demonstrated that antihypertensive treatment with doxazosin (DZN), an α-adrenergic blocker, and lisinopril (LIS), an ACE inhibitor, reverse glomerular sclerosis in corpulent spontaneously hypertensive rats with type 2 diabetes. In this study, we examined the effects of the above-mentioned antihypertensive drugs alone and in combination on the structure of interlobular and arcuate arteries in these rats. Both male and female rats aged 6 months were treated with antihypertensive drugs for 16 weeks. Various structural parameters were evaluated by light microscopy, with the use of digital image analysis, in kidney sections stained with periodic acid-Schiff. Systolic blood pressure was significantly lower in treated than in untreated rats. Untreated diabetic rats had a significantly higher media/lumen ratio (smaller luminal diameter) of both arteries compared with the ratio in treated rats (for interlobular artery, 0.72+0.06 [no treatment], 0.49±0.03 [DZN treatment], 0.54±0.06 [LIS treatment], and 0.52±0.04 [combination therapy], P<0.05 to <0.001 for no treatment versus treatment; for arcuate artery, 0.66±0.11 [no treatment], 0.40±0.02 [DZN treatment], 0.39±0.04 [LIS treatment], and 0.40±0.03 [combination therapy], P<0.05 for no treatment versus treatment). Antihypertensive treatment caused significant increases in total arterial cross-sectional area, internal and external diameters, luminal and medial cross-sectional area, and medial thickness in both interlobular and arcuate arteries. The improvement in arterial structure after antihypertensive treatment was due to remodeling and growth of the vessels. Both DZN and LIS were equally efficacious, and combination therapy had no additive or synergistic effect.

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KW - Angiotensin-converting enzyme inhibitors

KW - Arteries

KW - Diabetes mellitus

KW - Hypertension, experimental

KW - Kidney

KW - Rats, inbred SHR

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