Effect of labyrinthectomy on the endolymphatic sac: A histological, ultrastractural and computer-aided morphometric investigation in the mouse

Ulla Friberg; Phillip A. Wackym; Dan Bagger-Sjöbäck; Helge Rask-Andersen

doi:https://doi.org/10.3109/00016488609132825

Effect of labyrinthectomy on the endolymphatic sac: A histological, ultrastractural and computer-aided morphometric investigation in the mouse

Ulla Friberg, Phillip A. Wackym, Dan Bagger-Sjöbäck, Helge Rask-Andersen

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Abstract

A time sequence study of the effect of hemilabyrinthectomy on the endolymphatic sac was performed in mice. Light and transmission electron microscopy of the sac showed significant morphological changes of the epithelial lining and adjacent structures. Initially (2 and 4 days post-labyrinthectomy) the sac lumen was collapsed, but later (7 days post-labyrinthectomy) it was dilated or 'ballooned' and filled with a darkly staining homogeneous substance. This substance, which has been identified histochemically as a proteoglycan, appeared to be secreted from the epithelium of the endolymphatic sac. This finding suggests that the endolymphatic sac may be capable both of absorbing and of secreting endolymph.

Original language	English (US)
Pages (from-to)	172-182
Number of pages	11
Journal	Acta Oto-Laryngologica
Volume	101
Issue number	3-4
DOIs	https://doi.org/10.3109/00016488609132825
State	Published - 1986

ASJC Scopus subject areas

Otorhinolaryngology

Keywords

Endolymphatic sac
Labyrinthectomy
Mouse
Secretion

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https://doi.org/10.3109/00016488609132825

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title = "Effect of labyrinthectomy on the endolymphatic sac: A histological, ultrastractural and computer-aided morphometric investigation in the mouse",

abstract = "A time sequence study of the effect of hemilabyrinthectomy on the endolymphatic sac was performed in mice. Light and transmission electron microscopy of the sac showed significant morphological changes of the epithelial lining and adjacent structures. Initially (2 and 4 days post-labyrinthectomy) the sac lumen was collapsed, but later (7 days post-labyrinthectomy) it was dilated or 'ballooned' and filled with a darkly staining homogeneous substance. This substance, which has been identified histochemically as a proteoglycan, appeared to be secreted from the epithelium of the endolymphatic sac. This finding suggests that the endolymphatic sac may be capable both of absorbing and of secreting endolymph.",

keywords = "Endolymphatic sac, Labyrinthectomy, Mouse, Secretion",

author = "Ulla Friberg and Wackym, {Phillip A.} and Dan Bagger-Sj{\"o}b{\"a}ck and Helge Rask-Andersen",

note = "Funding Information: Mrs Birgitta Jansson is thanked for excellent technical assistance. This study was supported by the Swedish Medical Research Council (project 03908 H R-A).",

year = "1986",

doi = "https://doi.org/10.3109/00016488609132825",

language = "English (US)",

volume = "101",

pages = "172--182",

journal = "Acta Oto-Laryngologica",

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T2 - A histological, ultrastractural and computer-aided morphometric investigation in the mouse

AU - Friberg, Ulla

AU - Wackym, Phillip A.

AU - Bagger-Sjöbäck, Dan

AU - Rask-Andersen, Helge

N1 - Funding Information: Mrs Birgitta Jansson is thanked for excellent technical assistance. This study was supported by the Swedish Medical Research Council (project 03908 H R-A).

PY - 1986

Y1 - 1986

N2 - A time sequence study of the effect of hemilabyrinthectomy on the endolymphatic sac was performed in mice. Light and transmission electron microscopy of the sac showed significant morphological changes of the epithelial lining and adjacent structures. Initially (2 and 4 days post-labyrinthectomy) the sac lumen was collapsed, but later (7 days post-labyrinthectomy) it was dilated or 'ballooned' and filled with a darkly staining homogeneous substance. This substance, which has been identified histochemically as a proteoglycan, appeared to be secreted from the epithelium of the endolymphatic sac. This finding suggests that the endolymphatic sac may be capable both of absorbing and of secreting endolymph.

AB - A time sequence study of the effect of hemilabyrinthectomy on the endolymphatic sac was performed in mice. Light and transmission electron microscopy of the sac showed significant morphological changes of the epithelial lining and adjacent structures. Initially (2 and 4 days post-labyrinthectomy) the sac lumen was collapsed, but later (7 days post-labyrinthectomy) it was dilated or 'ballooned' and filled with a darkly staining homogeneous substance. This substance, which has been identified histochemically as a proteoglycan, appeared to be secreted from the epithelium of the endolymphatic sac. This finding suggests that the endolymphatic sac may be capable both of absorbing and of secreting endolymph.

KW - Endolymphatic sac

KW - Labyrinthectomy

KW - Mouse

KW - Secretion

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SP - 172

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JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

IS - 3-4

ER -

Effect of labyrinthectomy on the endolymphatic sac: A histological, ultrastractural and computer-aided morphometric investigation in the mouse

Abstract

ASJC Scopus subject areas

Keywords

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