Effect of systemic challenge with bacterial toxins on behaviors relevant to mood, anxiety and cognition

Rachel A. Kohman, Joanne M. Hash-Converse, Alexander Kusnecov

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Activation of the immune system is known to induce functional alterations in the central nervous system that subsequently modify behavior. However, the degree of influence the immune system has on mood and cognitive function remains in question. The present chapter begins with a focused discussion of the behavioral and neuroendocrine effects of superantigen exposure, a model that activates the immune system in a T-cell dependent manner. Administration of a superantigen induces gustatory neophobia, activation of the hypothalamic- pituitary adrenal axis, and activates brain regions associated with emotional behavior. The chapter ends with a review of the current literature on the effects of immune activation on learning and memory processes, in which most work has used the T cell independent endotoxin model and interleukin-1 administration. Whether cytokine production facilitates or disrupts cognitive function appears to be dependent on, among other factors, the dose, timing of immune challenge, and test procedure employed. Throughout the chapter is a discussion of the potential neural mechanisms of the mood and cognitive alterations association with an immunological challenge.

Original languageEnglish (US)
Title of host publicationThe Neuroimmunological Basis of Behavior and Mental Disorders
PublisherSpringer US
Pages183-208
Number of pages26
ISBN (Print)9780387848501
DOIs
StatePublished - Dec 1 2009

Fingerprint

Bacterial Toxins
Cognition
Immune System
Superantigens
Anxiety
T-Lymphocytes
Interleukin-1
Endotoxins
Central Nervous System
Learning
Cytokines
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Kohman, R. A., Hash-Converse, J. M., & Kusnecov, A. (2009). Effect of systemic challenge with bacterial toxins on behaviors relevant to mood, anxiety and cognition. In The Neuroimmunological Basis of Behavior and Mental Disorders (pp. 183-208). Springer US. https://doi.org/10.1007/978-0-387-84851-8_10
Kohman, Rachel A. ; Hash-Converse, Joanne M. ; Kusnecov, Alexander. / Effect of systemic challenge with bacterial toxins on behaviors relevant to mood, anxiety and cognition. The Neuroimmunological Basis of Behavior and Mental Disorders. Springer US, 2009. pp. 183-208
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Kohman, RA, Hash-Converse, JM & Kusnecov, A 2009, Effect of systemic challenge with bacterial toxins on behaviors relevant to mood, anxiety and cognition. in The Neuroimmunological Basis of Behavior and Mental Disorders. Springer US, pp. 183-208. https://doi.org/10.1007/978-0-387-84851-8_10

Effect of systemic challenge with bacterial toxins on behaviors relevant to mood, anxiety and cognition. / Kohman, Rachel A.; Hash-Converse, Joanne M.; Kusnecov, Alexander.

The Neuroimmunological Basis of Behavior and Mental Disorders. Springer US, 2009. p. 183-208.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Kohman RA, Hash-Converse JM, Kusnecov A. Effect of systemic challenge with bacterial toxins on behaviors relevant to mood, anxiety and cognition. In The Neuroimmunological Basis of Behavior and Mental Disorders. Springer US. 2009. p. 183-208 https://doi.org/10.1007/978-0-387-84851-8_10