Effective antibacterials: At what cost? The economics of antibacterial resistance and its control

Anthony R. White, Martin Blaser, Otto Carrs, Gail Cassell, Neil Fishman, Robert Guidos, Stuart Levy, John Powers, Ragnar Norrby, Glenn Tillotson, Rick Davies, Steven Projan, Mike Dawson, Dominique Monnet, Marcus Keogh-brown, Kieran Hand, Sarah Garner, David Findlay, Chantal Morel, Richard WiseRichard Bax, Frances Burke, Ian Chopra, Lloyd Czaplewski, Roger Finch, David Livermore, Laura J.V. Piddock, Tony White

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The original and successful business model of return on investment being sufficiently attractive to the pharmaceutical industry to encourage development of new antibacterial molecules and related diagnostics has been compromised by increasing development costs and regulatory hurdles, resulting in a decreasing chance of success and financial return. The supply of new effective agents is diminishing along with the number of companies engaged in antibacterial research and development. The BSAC Working Party on The Urgent Need:Regenerating Antibacterial Drug Discovery and Development identified the need to establish, communicate and apply the true health and economic value of antibacterials, along with the adoption of meaningful incentives, as part of the future model for antibacterial development. Robust data are needed on the cost of resistance and ineffective treatment of bacterial infection, along with national and local holistic analyses of the cost-benefit of antibacterials. An understanding of the true health and economic value of antibacterials and the cost of resistance across healthcare systems needs to be generated, communicated and used in order to set a pricing and reimbursement structure that is commensurate with value. The development and economic model of antibacterial use needs to be rebuilt based on this value through dialogue with the various stakeholders, including the pharmaceutical industry, and alternative incentives from 'push' to 'pull' and funding models, such as public/private partnerships, agreed. A research and development model that succeeds in developing and delivering new antibacterial agents that address the health needs of society from start to finish, 'from cradle to grave', must be established.

Original languageEnglish (US)
Article numberdkr260
Pages (from-to)1948-1953
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Volume66
Issue number9
DOIs
StatePublished - Sep 1 2011

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Economics
Costs and Cost Analysis
Drug Industry
Motivation
Health
Public-Private Sector Partnerships
Economic Models
Drug Discovery
Research
Bacterial Infections
Cost-Benefit Analysis
Anti-Bacterial Agents
Delivery of Health Care

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology

Keywords

  • Drug development
  • Estimated net present values
  • Return on investment

Cite this

White, Anthony R. ; Blaser, Martin ; Carrs, Otto ; Cassell, Gail ; Fishman, Neil ; Guidos, Robert ; Levy, Stuart ; Powers, John ; Norrby, Ragnar ; Tillotson, Glenn ; Davies, Rick ; Projan, Steven ; Dawson, Mike ; Monnet, Dominique ; Keogh-brown, Marcus ; Hand, Kieran ; Garner, Sarah ; Findlay, David ; Morel, Chantal ; Wise, Richard ; Bax, Richard ; Burke, Frances ; Chopra, Ian ; Czaplewski, Lloyd ; Finch, Roger ; Livermore, David ; Piddock, Laura J.V. ; White, Tony. / Effective antibacterials : At what cost? The economics of antibacterial resistance and its control. In: Journal of Antimicrobial Chemotherapy. 2011 ; Vol. 66, No. 9. pp. 1948-1953.
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White, AR, Blaser, M, Carrs, O, Cassell, G, Fishman, N, Guidos, R, Levy, S, Powers, J, Norrby, R, Tillotson, G, Davies, R, Projan, S, Dawson, M, Monnet, D, Keogh-brown, M, Hand, K, Garner, S, Findlay, D, Morel, C, Wise, R, Bax, R, Burke, F, Chopra, I, Czaplewski, L, Finch, R, Livermore, D, Piddock, LJV & White, T 2011, 'Effective antibacterials: At what cost? The economics of antibacterial resistance and its control', Journal of Antimicrobial Chemotherapy, vol. 66, no. 9, dkr260, pp. 1948-1953. https://doi.org/10.1093/jac/dkr260

Effective antibacterials : At what cost? The economics of antibacterial resistance and its control. / White, Anthony R.; Blaser, Martin; Carrs, Otto; Cassell, Gail; Fishman, Neil; Guidos, Robert; Levy, Stuart; Powers, John; Norrby, Ragnar; Tillotson, Glenn; Davies, Rick; Projan, Steven; Dawson, Mike; Monnet, Dominique; Keogh-brown, Marcus; Hand, Kieran; Garner, Sarah; Findlay, David; Morel, Chantal; Wise, Richard; Bax, Richard; Burke, Frances; Chopra, Ian; Czaplewski, Lloyd; Finch, Roger; Livermore, David; Piddock, Laura J.V.; White, Tony.

In: Journal of Antimicrobial Chemotherapy, Vol. 66, No. 9, dkr260, 01.09.2011, p. 1948-1953.

Research output: Contribution to journalArticle

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