Effective bioprinting resolution in tissue model fabrication

Amir K. Miri, Iman Mirzaee, Shabir Hassan, Shirin Mesbah Oskui, Daniel Nieto, Ali Khademhosseini, Yu Shrike Zhang

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Recent advancements in bioprinting techniques have enabled convenient fabrication of micro-tissues in organ-on-a-chip platforms. In a sense, the success of bioprinted micro-tissues depends on how close their architectures are to the anatomical features of their native counterparts. The bioprinting resolution largely relates to the technical specifications of the bioprinter platforms and the physicochemical properties of the bioinks. In this article, we compare inkjet, extrusion, and light-assisted bioprinting technologies for fabrication of micro-tissues towards construction of biomimetic organ-on-a-chip platforms. Our theoretical analyses reveal that for a given printhead diameter, surface contact angle dominates inkjet bioprinting resolution, while nozzle moving speed and the nonlinearity of viscosity for bioinks regulate extrusion bioprinting resolution. The resolution of light-assisted bioprinting is strongly affected by the photocrosslinking behavior and light characteristics. Our tutorial guideline for optimizing bioprinting resolution would potentially help model the complex microenvironment of biological tissues in organ-on-a-chip platforms.

Original languageEnglish (US)
Pages (from-to)2019-2037
Number of pages19
JournalLab on a Chip
Volume19
Issue number11
DOIs
StatePublished - Jun 7 2019

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Biochemistry
  • Biomedical Engineering

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