Effects of coronary artery reperfusion on regional myocardial blood flow and function in conscious baboons

G. R. Heyndrickx, J. Amano, T. A. Patrick, W. T. Manders, G. G. Rogers, C. Rosendorff, Stephen Vatner

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The effects of coronary artery reperfusion initiated 1 hr and 3 hr after coronary artery occlusion were evaluated on measurements of overall and regional left ventricular function and on regional myocardial blood flow. These experiments were conducted in conscious baboons 2 to 3 weeks after recovery from instrumentation with a solid state left ventricular pressure gauge, aortic and left atrial catheters, a hydraulic occluder around the mid left anterior descending coronary artery, and pairs of ultrasonic transducers implanted in the endocardium of the left ventricular free wall or across the free wall to measure endocardial segment shortening and wall thickening, respectively. Coronary artery occlusion induced similar effects in both groups. At 1 hr after occlusion, the ischemic zone was characterized by severe and equal reductions in both endocardial (-97 ± 1%) and epicardial (-95 ± 4%) blood flows and complete loss of regional systolic function, which was replaced by paradoxical wall motion. Reperfusion initiated after 1 hr of ischemia was associated with a marked transient increase in endocardial (+386 ± 51%) and epicardial (+544 ± 79%) blood flows. During the subsequent 4 weeks, segment shortening and wall thickening tended to improve. However, at 4 weeks after reperfusion, segment shortening was still depressed by 45 ± 12% and wall thickening by 58 ± 14%. In contrast, reperfusion initiated after 3 hr of ischemia was not associated with a significant hyperemic response, and systolic segment shortening and wall thickening did not recover during the subsequent 4 week period. Thus in the conscious baboon, coronary artery reperfusion at 1 hr elicits a marked coronary hyperemic response and results in partial return of regional myocardial function, whereas reperfusion after 23 hr results in neither hyperemia nor any salvage of regional systolic myocardial function.

Original languageEnglish (US)
Pages (from-to)1029-1037
Number of pages9
JournalCirculation
Volume71
Issue number5
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

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Myocardial Reperfusion
Papio
Regional Blood Flow
Coronary Vessels
Reperfusion
Coronary Occlusion
Ischemia
Endocardium
Hyperemia
Ventricular Pressure
Transducers
Left Ventricular Function
Ultrasonics
Catheters

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Heyndrickx, G. R., Amano, J., Patrick, T. A., Manders, W. T., Rogers, G. G., Rosendorff, C., & Vatner, S. (1985). Effects of coronary artery reperfusion on regional myocardial blood flow and function in conscious baboons. Circulation, 71(5), 1029-1037. https://doi.org/10.1161/01.CIR.71.5.1029
Heyndrickx, G. R. ; Amano, J. ; Patrick, T. A. ; Manders, W. T. ; Rogers, G. G. ; Rosendorff, C. ; Vatner, Stephen. / Effects of coronary artery reperfusion on regional myocardial blood flow and function in conscious baboons. In: Circulation. 1985 ; Vol. 71, No. 5. pp. 1029-1037.
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Heyndrickx, GR, Amano, J, Patrick, TA, Manders, WT, Rogers, GG, Rosendorff, C & Vatner, S 1985, 'Effects of coronary artery reperfusion on regional myocardial blood flow and function in conscious baboons', Circulation, vol. 71, no. 5, pp. 1029-1037. https://doi.org/10.1161/01.CIR.71.5.1029

Effects of coronary artery reperfusion on regional myocardial blood flow and function in conscious baboons. / Heyndrickx, G. R.; Amano, J.; Patrick, T. A.; Manders, W. T.; Rogers, G. G.; Rosendorff, C.; Vatner, Stephen.

In: Circulation, Vol. 71, No. 5, 01.01.1985, p. 1029-1037.

Research output: Contribution to journalArticle

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Heyndrickx GR, Amano J, Patrick TA, Manders WT, Rogers GG, Rosendorff C et al. Effects of coronary artery reperfusion on regional myocardial blood flow and function in conscious baboons. Circulation. 1985 Jan 1;71(5):1029-1037. https://doi.org/10.1161/01.CIR.71.5.1029