Effects of cyanate, thiocyanate, and amygdalin on metabolite uptake in normal and neoplastic tissues of the rat

Michael A. Lea, Michael R. Koch

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Thiocyanate was found to resemble cyanate In Its Inhibitory effects on [3H]thymidine Incorporation and the uptake of [32P]phosphate and [3H]amino acids In transplanted tumors of the BUF rat. The capacity to inhibit metabolite uptake In hepatomas and a colon tumor under conditions In which uptake was unchanged or Increased In host liver was concluded to be a common feature of the action of cyanate and thiocyanate. Inhibition of [32P]phosphate uptake and [3H]thymidlne Incorporation Into DNA of tumors was also observed after treatment of rats with amygdalin. With this drug, however, the action on tumors and livers of host rats was similar.

Original languageEnglish (US)
Pages (from-to)1279-1283
Number of pages5
JournalJournal of the National Cancer Institute
Volume63
Issue number5
DOIs
StatePublished - Nov 1979

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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