TY - JOUR
T1 - Effects of Terminal Sterilization on PEG-Based Bioresorbable Polymers Used in Biomedical Applications
AU - Bhatnagar, Divya
AU - Dube, Koustubh
AU - Damodaran, Vinod B.
AU - Subramanian, Ganesan
AU - Aston, Kenneth
AU - Halperin, Frederick
AU - Mao, Meiyu
AU - Pricer, Kurt
AU - Murthy, N. Sanjeeva
AU - Kohn, Joachim
N1 - Publisher Copyright: © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2016/10/1
Y1 - 2016/10/1
N2 - The effects of ethylene oxide (EO), vaporized hydrogen peroxide (VHP), gamma (γ) radiation, and electron-beam (E-beam) on the physiochemical and morphological properties of medical device polymers are investigated. Polymers with ether, carbonate, carboxylic acid, amide and ester functionalities are selected from a family of poly(ethylene glycol) (PEG) containing tyrosine-derived polycarbonates (TyrPCs) to include slow, medium, fast, and ultra-fast degrading polymers. Poly(lactic acid) (PLA) is used for comparison. Molecular weight (Mw) of all tested polymers decreases upon gamma and E-beam, and this effect becomes more pronounced at higher PEG content. Gamma sterilization increases the glass transition temperature of polymers with high PEG content. EO esterifies the carboxylic acid groups in desaminotyrosol-tyrosine (DT) and causes significant degradation. VHP causes hydroxylation of the phenyl ring, and hydrolytic degradation. This study signifies the importance of the chemical composition when selecting a sterilization method, and provides suggested conditions for each of the sterilization methods. (Figure presented.).
AB - The effects of ethylene oxide (EO), vaporized hydrogen peroxide (VHP), gamma (γ) radiation, and electron-beam (E-beam) on the physiochemical and morphological properties of medical device polymers are investigated. Polymers with ether, carbonate, carboxylic acid, amide and ester functionalities are selected from a family of poly(ethylene glycol) (PEG) containing tyrosine-derived polycarbonates (TyrPCs) to include slow, medium, fast, and ultra-fast degrading polymers. Poly(lactic acid) (PLA) is used for comparison. Molecular weight (Mw) of all tested polymers decreases upon gamma and E-beam, and this effect becomes more pronounced at higher PEG content. Gamma sterilization increases the glass transition temperature of polymers with high PEG content. EO esterifies the carboxylic acid groups in desaminotyrosol-tyrosine (DT) and causes significant degradation. VHP causes hydroxylation of the phenyl ring, and hydrolytic degradation. This study signifies the importance of the chemical composition when selecting a sterilization method, and provides suggested conditions for each of the sterilization methods. (Figure presented.).
KW - biodegradable
KW - biomaterials
KW - poly(ethylene glycol)
KW - sterilization
KW - structure–property relations
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U2 - 10.1002/mame.201600133
DO - 10.1002/mame.201600133
M3 - Article
SN - 1438-7492
VL - 301
SP - 1211
EP - 1224
JO - Macromolecular Materials and Engineering
JF - Macromolecular Materials and Engineering
IS - 10
ER -