TY - JOUR
T1 - Electrochemical reduction of artemisinin
T2 - Chromatographic identification of bulk electrolysis products
AU - Obwayo, Faraja
AU - Mazzochette, Zahilis
AU - Mugweru, Amos
N1 - Funding Information: Acknowledgements: We would like to acknowledge the department of Chemistry and Biochemistry Rowan University for support of this project. Publisher Copyright: © 2019 by the authors.
PY - 2019/5/6
Y1 - 2019/5/6
N2 - Artemisinin is a naturally occurring sesquiterpene lactone with an endo-peroxide bond. This drug is used for treatment of many diseases including malaria. The reduction of this molecule on an electrode surface was carried out by cyclic voltammetry as well as amperometry. Cyclic voltammetry of artemisinin generated one prominent peak wave at -1.0 V and another, smaller one at -0.3 V vs Ag/AgCl reference electrode. The bulk electrolysis of artemisinin on a carbon electrode generated two other irreversible peak waves at around -0.7 and -0.1 V. The concentration of the products was dependent on the time of electrolysis. LC-MS was used to determine the bulk electrolysis products of artemisinin. Initially dihydroartemisinin was generated as the main reduction product. Other reduction products were formed after further reduction of dyhidroartemisinin.
AB - Artemisinin is a naturally occurring sesquiterpene lactone with an endo-peroxide bond. This drug is used for treatment of many diseases including malaria. The reduction of this molecule on an electrode surface was carried out by cyclic voltammetry as well as amperometry. Cyclic voltammetry of artemisinin generated one prominent peak wave at -1.0 V and another, smaller one at -0.3 V vs Ag/AgCl reference electrode. The bulk electrolysis of artemisinin on a carbon electrode generated two other irreversible peak waves at around -0.7 and -0.1 V. The concentration of the products was dependent on the time of electrolysis. LC-MS was used to determine the bulk electrolysis products of artemisinin. Initially dihydroartemisinin was generated as the main reduction product. Other reduction products were formed after further reduction of dyhidroartemisinin.
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U2 - https://doi.org/10.5599/jese.652
DO - https://doi.org/10.5599/jese.652
M3 - Article
SN - 1847-9286
VL - 9
SP - 165
EP - 174
JO - Journal of Electrochemical Science and Engineering
JF - Journal of Electrochemical Science and Engineering
IS - 3
ER -