Electrolytic lesions in the depressor area of the ventrolateral medulla of the rat abolish depressor responses to the aortic nerve stimulation

Jaya Murugaian, Kalyana Sundaram, Abbott Krieger

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

The pressor (VLPA) and the depressor (VLDA) areas in the ventrolateral medulla were identified with the microinjections of l-glutamate (1.77 nmol/site) in artificially ventilated, pentobarbital-anesthetized male Wistar rats. Electrical stimulation of the left or right aortic nerve (1-6 V, 10-40 pulses/s, 3 ms) produced usual deprossor responses. Electrolytic lesions (2.5 mA for 30 s) were placed bilaterally in the VLDA. Lack of responses to subsequent microinjections of glutamate into the VLDA indicated that the lesions were complete. The function of the VLPA was not compromised because it continued to respond to microinjections of glutamate. Subsequent stimulation of the aortic nerves failed to elicit the usual depressor responses. These results confirm our earlier reports indicating that the VLDA is important in mediating the depressor component of the aortic baroreflex.

Original languageEnglish (US)
Pages (from-to)371-377
Number of pages7
JournalBrain Research
Volume499
Issue number2
DOIs
StatePublished - Oct 16 1989

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • Baroreflex
  • Blood pressure
  • Glutamate
  • Heart rate
  • Lidocaine
  • Muscimol
  • Ventrolateral medullary pressor area

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