Electrospun pullulan based nanofibers for medical applications

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

There are over 100 million people in the United States living with diabetes; of these, roughly 20 million will be diagnosed with either a hand or foot ulcer in their lifetime. These ulcers form due to a wide range of causes, but they rarely heal, and often become a chronic condition, due to necrosis of the tissue and deficiencies caused by the patient’s diabetes {reference}. Common treatment for these ulcers range from removal of dead tissue to angioplasty to increase the blood flow to amputation of the afflicted limb, which leads to multiple returns to hospitals and clinics, or permanent loss of limb. Nanofibers have been used with increasing success for drug delivery due to their extremely high surface to volume ratio, low density, and high porosity. Aloe Vera has been used for millennia for its curative and wound healing properties. In order to prevent aloe vera from degrading, it can be spun into nanofibers to preserve its curative properties. It is hypothesized that consistently thin nanofibers created using aloe vera as a base can aid in recovery time for diabetic ulcers. Pullulan, a plastic commonly used in the food industry, is water soluble, biodegradable, and has high adhesion, making it the perfect candidate for electrospinning.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Fingerprint

Aloe
Nanofibers
Ulcer
Extremities
Foot Ulcer
Food Industry
Porosity
Amputation
Angioplasty
Wound Healing
Plastics
Necrosis
Hand
Water
Pharmaceutical Preparations
pullulan
Therapeutics

All Science Journal Classification (ASJC) codes

  • Materials Chemistry
  • Biophysics
  • Biochemistry
  • Biotechnology
  • Biomaterials

Cite this

Bossart, A., Shady, S., & Kalyon, D. (2019). Electrospun pullulan based nanofibers for medical applications. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.
Bossart, A. ; Shady, Sally ; Kalyon, Dilhan. / Electrospun pullulan based nanofibers for medical applications. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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abstract = "There are over 100 million people in the United States living with diabetes; of these, roughly 20 million will be diagnosed with either a hand or foot ulcer in their lifetime. These ulcers form due to a wide range of causes, but they rarely heal, and often become a chronic condition, due to necrosis of the tissue and deficiencies caused by the patient’s diabetes {reference}. Common treatment for these ulcers range from removal of dead tissue to angioplasty to increase the blood flow to amputation of the afflicted limb, which leads to multiple returns to hospitals and clinics, or permanent loss of limb. Nanofibers have been used with increasing success for drug delivery due to their extremely high surface to volume ratio, low density, and high porosity. Aloe Vera has been used for millennia for its curative and wound healing properties. In order to prevent aloe vera from degrading, it can be spun into nanofibers to preserve its curative properties. It is hypothesized that consistently thin nanofibers created using aloe vera as a base can aid in recovery time for diabetic ulcers. Pullulan, a plastic commonly used in the food industry, is water soluble, biodegradable, and has high adhesion, making it the perfect candidate for electrospinning.",
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Bossart, A, Shady, S & Kalyon, D 2019, Electrospun pullulan based nanofibers for medical applications. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.

Electrospun pullulan based nanofibers for medical applications. / Bossart, A.; Shady, Sally; Kalyon, Dilhan.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Bossart A, Shady S, Kalyon D. Electrospun pullulan based nanofibers for medical applications. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).