Elicitation, a new window into plant chemodiversity and phytochemical drug discovery

Alexander Poulev, Joseph M. O'Neal, Sithes Logendra, Reneta B. Pouleva, Vesa Timeva, Alison S. Garvey, Doloressa Gleba, Ivan S. Jenkins, Barbara T. Halpern, Ralf Kneer, Gordon M. Cragg, Ilya Raskin

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Plant extracts collected from the wild are important sources for drug discovery. However, these extracts suffer from a lack of reproducible bioactivity and chemical composition caused by the highly inducible, variable, and transitory nature of plant secondary metabolism. Here, we demonstrate that exposing roots of hydroponically grown plants to chemical elicitors selectively and reproducibly induced the production of bioactive compounds, dramatically increased the hit rate, and more than doubled the number of plant species showing in vitro activity against bacteria, fungi, or cancer. Elicitation performed under controlled conditions dramatically improves reliability and efficiency of plant extracts in drug discovery while preserving wild species and their habitats.

Original languageEnglish (US)
Pages (from-to)2542-2547
Number of pages6
JournalJournal of medicinal chemistry
Volume46
Issue number12
DOIs
StatePublished - Jun 5 2003

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Phytochemicals
Drug Discovery
Plant Extracts
Secondary Metabolism
Ecosystem
Fungi
Bacteria
Neoplasms

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Molecular Medicine

Cite this

Poulev, A., O'Neal, J. M., Logendra, S., Pouleva, R. B., Timeva, V., Garvey, A. S., ... Raskin, I. (2003). Elicitation, a new window into plant chemodiversity and phytochemical drug discovery. Journal of medicinal chemistry, 46(12), 2542-2547. https://doi.org/10.1021/jm020359t
Poulev, Alexander ; O'Neal, Joseph M. ; Logendra, Sithes ; Pouleva, Reneta B. ; Timeva, Vesa ; Garvey, Alison S. ; Gleba, Doloressa ; Jenkins, Ivan S. ; Halpern, Barbara T. ; Kneer, Ralf ; Cragg, Gordon M. ; Raskin, Ilya. / Elicitation, a new window into plant chemodiversity and phytochemical drug discovery. In: Journal of medicinal chemistry. 2003 ; Vol. 46, No. 12. pp. 2542-2547.
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Poulev, A, O'Neal, JM, Logendra, S, Pouleva, RB, Timeva, V, Garvey, AS, Gleba, D, Jenkins, IS, Halpern, BT, Kneer, R, Cragg, GM & Raskin, I 2003, 'Elicitation, a new window into plant chemodiversity and phytochemical drug discovery', Journal of medicinal chemistry, vol. 46, no. 12, pp. 2542-2547. https://doi.org/10.1021/jm020359t

Elicitation, a new window into plant chemodiversity and phytochemical drug discovery. / Poulev, Alexander; O'Neal, Joseph M.; Logendra, Sithes; Pouleva, Reneta B.; Timeva, Vesa; Garvey, Alison S.; Gleba, Doloressa; Jenkins, Ivan S.; Halpern, Barbara T.; Kneer, Ralf; Cragg, Gordon M.; Raskin, Ilya.

In: Journal of medicinal chemistry, Vol. 46, No. 12, 05.06.2003, p. 2542-2547.

Research output: Contribution to journalArticle

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Poulev A, O'Neal JM, Logendra S, Pouleva RB, Timeva V, Garvey AS et al. Elicitation, a new window into plant chemodiversity and phytochemical drug discovery. Journal of medicinal chemistry. 2003 Jun 5;46(12):2542-2547. https://doi.org/10.1021/jm020359t