Embryonic stem cell-specific microRNAs

TY - JOUR

T1 - Embryonic stem cell-specific microRNAs

AU - Houbaviy, Hristo B.

AU - Murray, Michael F.

AU - Sharp, Phillip A.

PY - 2003/8/1

Y1 - 2003/8/1

N2 - We have identified microRNAs (miRNAs) in undifferentiated and differentiated mouse embryonic stem (ES) cells. Some of these appear to be ES cell specific, have related sequences, and are encoded by genomic loci clustered within 2.2 kb of each other. Their expression is repressed as ES cells differentiate into embryoid bodies and is undetectable in adult mouse organs. In contrast, the levels of many previously described miRNAs remain constant or increase upon differentiation. Our results suggest that miRNAs may have a role in the maintenance of the pluripotent cell state and in the regulation of early mammalian development.

AB - We have identified microRNAs (miRNAs) in undifferentiated and differentiated mouse embryonic stem (ES) cells. Some of these appear to be ES cell specific, have related sequences, and are encoded by genomic loci clustered within 2.2 kb of each other. Their expression is repressed as ES cells differentiate into embryoid bodies and is undetectable in adult mouse organs. In contrast, the levels of many previously described miRNAs remain constant or increase upon differentiation. Our results suggest that miRNAs may have a role in the maintenance of the pluripotent cell state and in the regulation of early mammalian development.

UR - https://www.scopus.com/pages/publications/0042442335

UR - https://www.scopus.com/pages/publications/0042442335#tab=citedBy

U2 - 10.1016/S1534-5807(03)00227-2

DO - 10.1016/S1534-5807(03)00227-2

M3 - Article

C2 - 12919684

SN - 1534-5807

VL - 5

SP - 351

EP - 358

JO - Developmental cell

JF - Developmental cell

IS - 2

ER -