Emerging imaging modalities for functional assessment of donor lungs ex vivo

Maria R. Hudock; Meghan R. Pinezich; Seyed Mohammad Mir; Jiawen Chen; Matthew Bacchetta; Gordana Vunjak-Novakovic; Jinho Kim

doi:10.1016/j.cobme.2022.100432

Emerging imaging modalities for functional assessment of donor lungs ex vivo

Maria R. Hudock, Meghan R. Pinezich, Seyed Mohammad Mir, Jiawen Chen, Matthew Bacchetta, Gordana Vunjak-Novakovic, Jinho Kim

Department of Biomedical Engineering

Stevens Institute of Technology

Research output: Contribution to journal › Review article › peer-review

Abstract

The severe shortage of functional donor lungs that can be offered to recipients has been a major challenge in lung transplantation. Innovative ex vivo lung perfusion (EVLP) and tissue engineering methodologies are now being developed to repair damaged donor lungs that are deemed unsuitable for transplantation. To assess the efficacy of donor lung reconditioning methods intended to rehabilitate rejected donor lungs, monitoring of lung function with improved spatiotemporal resolution is needed. Recent developments in live imaging are enabling non-destructive, direct, and longitudinal modalities for assessing local tissue and whole lung functions. In this review, we describe how emerging live imaging modalities can be coupled with lung tissue engineering approaches to promote functional recovery of ex vivo donor lungs.

Original language	English
Article number	100432
Journal	Current Opinion in Biomedical Engineering
Volume	25
DOIs	https://doi.org/10.1016/j.cobme.2022.100432
State	Published - Mar 2023

All Science Journal Classification (ASJC) codes

Bioengineering
Medicine (miscellaneous)
Biomaterials
Biomedical Engineering

Keywords

Donor lung reconditioning
Ex vivo lung Perfusion
Imaging
Lung transplantation
Tissue engineering

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10.1016/j.cobme.2022.100432

Cite this

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title = "Emerging imaging modalities for functional assessment of donor lungs ex vivo",

abstract = "The severe shortage of functional donor lungs that can be offered to recipients has been a major challenge in lung transplantation. Innovative ex vivo lung perfusion (EVLP) and tissue engineering methodologies are now being developed to repair damaged donor lungs that are deemed unsuitable for transplantation. To assess the efficacy of donor lung reconditioning methods intended to rehabilitate rejected donor lungs, monitoring of lung function with improved spatiotemporal resolution is needed. Recent developments in live imaging are enabling non-destructive, direct, and longitudinal modalities for assessing local tissue and whole lung functions. In this review, we describe how emerging live imaging modalities can be coupled with lung tissue engineering approaches to promote functional recovery of ex vivo donor lungs.",

keywords = "Donor lung reconditioning, Ex vivo lung Perfusion, Imaging, Lung transplantation, Tissue engineering",

author = "Hudock, {Maria R.} and Pinezich, {Meghan R.} and Mir, {Seyed Mohammad} and Jiawen Chen and Matthew Bacchetta and Gordana Vunjak-Novakovic and Jinho Kim",

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doi = "10.1016/j.cobme.2022.100432",

language = "English",

volume = "25",

journal = "Current Opinion in Biomedical Engineering",

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T1 - Emerging imaging modalities for functional assessment of donor lungs ex vivo

AU - Hudock, Maria R.

AU - Pinezich, Meghan R.

AU - Mir, Seyed Mohammad

AU - Chen, Jiawen

AU - Bacchetta, Matthew

AU - Vunjak-Novakovic, Gordana

AU - Kim, Jinho

PY - 2023/3

Y1 - 2023/3

N2 - The severe shortage of functional donor lungs that can be offered to recipients has been a major challenge in lung transplantation. Innovative ex vivo lung perfusion (EVLP) and tissue engineering methodologies are now being developed to repair damaged donor lungs that are deemed unsuitable for transplantation. To assess the efficacy of donor lung reconditioning methods intended to rehabilitate rejected donor lungs, monitoring of lung function with improved spatiotemporal resolution is needed. Recent developments in live imaging are enabling non-destructive, direct, and longitudinal modalities for assessing local tissue and whole lung functions. In this review, we describe how emerging live imaging modalities can be coupled with lung tissue engineering approaches to promote functional recovery of ex vivo donor lungs.

AB - The severe shortage of functional donor lungs that can be offered to recipients has been a major challenge in lung transplantation. Innovative ex vivo lung perfusion (EVLP) and tissue engineering methodologies are now being developed to repair damaged donor lungs that are deemed unsuitable for transplantation. To assess the efficacy of donor lung reconditioning methods intended to rehabilitate rejected donor lungs, monitoring of lung function with improved spatiotemporal resolution is needed. Recent developments in live imaging are enabling non-destructive, direct, and longitudinal modalities for assessing local tissue and whole lung functions. In this review, we describe how emerging live imaging modalities can be coupled with lung tissue engineering approaches to promote functional recovery of ex vivo donor lungs.

KW - Donor lung reconditioning

KW - Ex vivo lung Perfusion

KW - Imaging

KW - Lung transplantation

KW - Tissue engineering

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DO - 10.1016/j.cobme.2022.100432

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JO - Current Opinion in Biomedical Engineering

JF - Current Opinion in Biomedical Engineering

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ER -

Emerging imaging modalities for functional assessment of donor lungs ex vivo

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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