Emerging mediators of airway smooth muscle dysfunction in asthma

Behzad Yeganeh, Connie Xia, Hesam Movassagh, Cynthia Koziol-White, Ying Chang, Laila Al-Alwan, Jane E. Bourke, Brian G.G. Oliver

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Phenotypic changes in airway smooth muscle are integral to the pathophysiological changes that constitute asthma - namely inflammation, airway wall remodelling and bronchial hyperresponsiveness. In vitro and in vivo studies have shown that the proliferative, secretory and contractile functions of airway smooth muscle are dysfunctional in asthma. These functions can be modulated by various mediators whose levels are altered in asthma, derived from inflammatory cells or produced by airway smooth muscle itself. In this review, we describe the emerging roles of the CXC chemokines (GROs, IP-10), Th17-derived cytokines (IL-17, IL-22) and semaphorins, as well as the influence of viral infection on airway smooth muscle function, with a view to identifying new opportunities for therapeutic intervention in asthma.

Original languageEnglish (US)
Pages (from-to)105-111
Number of pages7
JournalPulmonary Pharmacology and Therapeutics
Volume26
Issue number1
DOIs
StatePublished - Feb 1 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, medical
  • Pharmacology (medical)
  • Pulmonary and Respiratory Medicine

Keywords

  • Airway smooth muscle
  • Asthma

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    Yeganeh, B., Xia, C., Movassagh, H., Koziol-White, C., Chang, Y., Al-Alwan, L., Bourke, J. E., & Oliver, B. G. G. (2013). Emerging mediators of airway smooth muscle dysfunction in asthma. Pulmonary Pharmacology and Therapeutics, 26(1), 105-111. https://doi.org/10.1016/j.pupt.2012.06.011