Endoscopic and histologic utility of transnasal endoscopy in pediatric eosinophilic esophagitis

Eliana Shaul; Kanak V. Kennedy; Zachary C. Spergel; Shanaz Daneshdoost; Mark Mahon; Shivani Thanawala; Jonathan M. Spergel; Benjamin Wilkins; Matthew J. Ryan; Amanda B. Muir

doi:10.1002/jpn3.12170

Endoscopic and histologic utility of transnasal endoscopy in pediatric eosinophilic esophagitis

Eliana Shaul
, Kanak V. Kennedy
, Zachary C. Spergel
, Shanaz Daneshdoost
, Mark Mahon
, Shivani Thanawala
, Jonathan M. Spergel
, Benjamin Wilkins
, Matthew J. Ryan
, Amanda B. Muir

School of Medicine

Hackensack Meridian School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Unsedated transnasal endoscopy (TNE) is an alternative method of examining the esophageal mucosa in pediatric patients with eosinophilic esophagitis (EoE), reducing cost, time, and risk associated with frequent surveillance esophagogastroduodenoscopies (EGD). Adequacy of transnasal esophageal biopsies for the evaluation of eosinophilic esophagitis histologic scoring system (EoEHSS) has not yet been evaluated. We compared procedure times, endoscopic findings, and EoEHSS scoring for EoE patients undergoing TNE versus standard EGD. Sixty-six TNE patients and 132 EGD controls matched for age (mean age 14.0 years) and disease status (29.3% active) were included. Compared to patients undergoing standard EGD, patients undergoing TNE spent 1.94 h less in the GI suite (p < 0.0001), with comparable occurrence rates of all visual endoscopic findings and most EoEHSS components. TNE serves as a useful tool for long-term disease surveillance, and consideration should be given to its use in clinical trials for EoE.

Original language	English
Pages (from-to)	1155-1160
Number of pages	6
Journal	Journal of pediatric gastroenterology and nutrition
Volume	78
Issue number	5
DOIs	https://doi.org/10.1002/jpn3.12170
State	Published - May 2024

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Gastroenterology

Keywords

histology
upper endoscopy

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10.1002/jpn3.12170

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title = "Endoscopic and histologic utility of transnasal endoscopy in pediatric eosinophilic esophagitis",

abstract = "Unsedated transnasal endoscopy (TNE) is an alternative method of examining the esophageal mucosa in pediatric patients with eosinophilic esophagitis (EoE), reducing cost, time, and risk associated with frequent surveillance esophagogastroduodenoscopies (EGD). Adequacy of transnasal esophageal biopsies for the evaluation of eosinophilic esophagitis histologic scoring system (EoEHSS) has not yet been evaluated. We compared procedure times, endoscopic findings, and EoEHSS scoring for EoE patients undergoing TNE versus standard EGD. Sixty-six TNE patients and 132 EGD controls matched for age (mean age 14.0 years) and disease status (29.3\% active) were included. Compared to patients undergoing standard EGD, patients undergoing TNE spent 1.94 h less in the GI suite (p < 0.0001), with comparable occurrence rates of all visual endoscopic findings and most EoEHSS components. TNE serves as a useful tool for long-term disease surveillance, and consideration should be given to its use in clinical trials for EoE.",

keywords = "histology, upper endoscopy",

author = "Eliana Shaul and Kennedy, \{Kanak V.\} and Spergel, \{Zachary C.\} and Shanaz Daneshdoost and Mark Mahon and Shivani Thanawala and Spergel, \{Jonathan M.\} and Benjamin Wilkins and Ryan, \{Matthew J.\} and Muir, \{Amanda B.\}",

note = "Publisher Copyright: {\textcopyright} 2024 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.",

year = "2024",

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doi = "10.1002/jpn3.12170",

language = "English",

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AU - Shaul, Eliana

AU - Kennedy, Kanak V.

AU - Spergel, Zachary C.

AU - Daneshdoost, Shanaz

AU - Mahon, Mark

AU - Thanawala, Shivani

AU - Spergel, Jonathan M.

AU - Wilkins, Benjamin

AU - Ryan, Matthew J.

AU - Muir, Amanda B.

PY - 2024/5

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N2 - Unsedated transnasal endoscopy (TNE) is an alternative method of examining the esophageal mucosa in pediatric patients with eosinophilic esophagitis (EoE), reducing cost, time, and risk associated with frequent surveillance esophagogastroduodenoscopies (EGD). Adequacy of transnasal esophageal biopsies for the evaluation of eosinophilic esophagitis histologic scoring system (EoEHSS) has not yet been evaluated. We compared procedure times, endoscopic findings, and EoEHSS scoring for EoE patients undergoing TNE versus standard EGD. Sixty-six TNE patients and 132 EGD controls matched for age (mean age 14.0 years) and disease status (29.3% active) were included. Compared to patients undergoing standard EGD, patients undergoing TNE spent 1.94 h less in the GI suite (p < 0.0001), with comparable occurrence rates of all visual endoscopic findings and most EoEHSS components. TNE serves as a useful tool for long-term disease surveillance, and consideration should be given to its use in clinical trials for EoE.

AB - Unsedated transnasal endoscopy (TNE) is an alternative method of examining the esophageal mucosa in pediatric patients with eosinophilic esophagitis (EoE), reducing cost, time, and risk associated with frequent surveillance esophagogastroduodenoscopies (EGD). Adequacy of transnasal esophageal biopsies for the evaluation of eosinophilic esophagitis histologic scoring system (EoEHSS) has not yet been evaluated. We compared procedure times, endoscopic findings, and EoEHSS scoring for EoE patients undergoing TNE versus standard EGD. Sixty-six TNE patients and 132 EGD controls matched for age (mean age 14.0 years) and disease status (29.3% active) were included. Compared to patients undergoing standard EGD, patients undergoing TNE spent 1.94 h less in the GI suite (p < 0.0001), with comparable occurrence rates of all visual endoscopic findings and most EoEHSS components. TNE serves as a useful tool for long-term disease surveillance, and consideration should be given to its use in clinical trials for EoE.

KW - histology

KW - upper endoscopy

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DO - 10.1002/jpn3.12170

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SN - 0277-2116

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SP - 1155

EP - 1160

JO - Journal of pediatric gastroenterology and nutrition

JF - Journal of pediatric gastroenterology and nutrition

IS - 5

ER -

Endoscopic and histologic utility of transnasal endoscopy in pediatric eosinophilic esophagitis

Abstract

ASJC Scopus subject areas

Keywords

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