Endoscopic imaging of the human vocal cords using polarization-sensitive optical coherence tomography

Mark C. Pierce, Adam Klein, James A. Burns, Milen Shishkov, B. Hyle Park, Guillermo J. Tearney, Brett E. Bouma, Steven M. Zeitels, Johannes F. De Boer

Research output: Contribution to journalConference articlepeer-review

Abstract

Endoscopie polarization-sensitive optical coherence tomography (PS-OCT) was used to obtain cross-sectional images of laryngeal tissues in human subjects, in vivo. Imaging in tissue to a depth of 1.2 mm and with axial resolution below 10 μm enabled the epithelial layer to be readily identified in OCT intensity images, with the underlying superficial lamina propria characterized by an increased backscatter signal, and increased birefringence in polarization-sensitive images.

Original languageEnglish (US)
Article number69
Pages (from-to)307-309
Number of pages3
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume5686
DOIs
StatePublished - 2005
Externally publishedYes
EventPhotonic Therapeutics and Diagnostics - San Jose, CA, United States
Duration: Jan 22 2005Jan 25 2005

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Biomaterials

Keywords

  • Birefringence
  • Cartilage
  • Fiber-optic probes
  • Optical imaging
  • Otolaryngology

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