Enhanced morphine preference following prolonged abstinence: Association with increased fos expressionin the extended amygdala

Glenda C. Harris, Gary Aston-Jones

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

We previously found that chronically morphine-pretreated, abstinent rats show stronger preferences for morphine-associated environments than placebo-pretreated rats. Here we show that this increased preference persisted for at least 5 weeks after withdrawal of chronic morphine. To determine brain regions involved in this behavior, we examined neural activation (as indexed by Fos-like proteins) induced by a morphine-conditioned place preference test. Placebo-pretreated (P) morphine-conditioned rats showed significantly elevated Fos in the anterior cingulate cortex (Cg), nucleus accumbens core (Ac-C) and shell(Ac-S), ventral lateral and dorsallateral bed nucleus of the stria terminialis (BNST-VL and -DL), and centraland basolateralamygdala nuclei(ACE, ABL) when compared to nonconditioned P rats. Chronically morphine-pretreated (M) rats that exhibited enhanced morphine preference 5 weeks after morphine withdrawal showed significantly greater Fos in allthe same areas except the BNST-DL relative to conditioned P ornonconditioned M rats. Place preference measures and Fos expression were positively correlated in the Cg and ABL, for conditioned Panimals, and in the Cg, ABL and BNST-VL for conditioned M animals. These results indicate a relationship between place preference behavior and neuralindices of activation in the forebrain in response to morphine-conditioned cues that may be chronically modulatedby prior morphine exposure.

Original languageEnglish (US)
Pages (from-to)292-299
Number of pages8
JournalNeuropsychopharmacology
Volume28
Issue number2
DOIs
StatePublished - Dec 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Pharmacology

Keywords

  • Accumbens
  • Amygdale
  • Bnst
  • C-Fos
  • Cingulate cortex
  • Conditioned place preference
  • Morphine
  • Morphine dependence

Fingerprint Dive into the research topics of 'Enhanced morphine preference following prolonged abstinence: Association with increased fos expressionin the extended amygdala'. Together they form a unique fingerprint.

  • Cite this