Enterobacter cloacae complex sequence type 171 isolates expressing KPC-4 carbapenemase recovered from canine patients in Ohio

Joshua B. Daniels, Liang Chen, Susan V. Grooters, Dixie F. Mollenkopf, Dimitria A. Mathys, Preeti Pancholi, Barry N. Kreiswirth, Thomas E. Wittum

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Companion animals are likely relevant in the transmission of antimicrobial-resistant bacteria. Enterobacter xiangfangensis sequence type 171 (ST171), a clone that has been implicated in clusters of infections in humans, was isolated from two dogs with clinical disease in Ohio. The canine isolates contained IncHI2 plasmids encoding blaKPC-4. Whole-genome sequencing was used to put the canine isolates in phylogenetic context with available human ST171 sequences, as well as to characterize their blaKPC-4 plasmids.

Original languageAmerican English
Article numbere01161-18
JournalAntimicrobial agents and chemotherapy
Volume62
Issue number12
DOIs
StatePublished - Dec 2018

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Keywords

  • Antibiotic resistance
  • Carbapenemase
  • Plasmid-mediated resistance
  • Veterinary microbiology

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