Enterocyte fatty acid-binding proteins (FABPs): Different functions of liver and intestinal FABPs in the intestine

TY - JOUR

T1 - Enterocyte fatty acid-binding proteins (FABPs)

T2 - Different functions of liver and intestinal FABPs in the intestine

AU - Gajda, Angela M.

AU - Storch, Judith

N1 - Publisher Copyright: © 2014 Elsevier Ltd.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Fatty acid-binding proteins (FABP) are highly abundant cytosolic proteins that are expressed in most mammalian tissues. In the intestinal enterocyte, both liver- (LFABP; FABP1) and intestinal FABPs (IFABP; FABP2) are expressed. These proteins display high-affinity binding for long-chain fatty acids (FA) and other hydrophobic ligands; thus, they are believed to be involved with uptake and trafficking of lipids in the intestine. In vitro studies have identified differences in ligand-binding stoichiometry and specificity, and in mechanisms of FA transfer to membranes, and it has been hypothesized that LFABP and IFABP have different functions in the enterocyte. Studies directly comparing LFABP- and IFABP-null mice have revealed markedly different phenotypes, indicating that these proteins indeed have different functions in intestinal lipid metabolism and whole body energy homeostasis. In this review, we discuss the evolving knowledge of the functions of LFABP and IFABP in the intestinal enterocyte.

AB - Fatty acid-binding proteins (FABP) are highly abundant cytosolic proteins that are expressed in most mammalian tissues. In the intestinal enterocyte, both liver- (LFABP; FABP1) and intestinal FABPs (IFABP; FABP2) are expressed. These proteins display high-affinity binding for long-chain fatty acids (FA) and other hydrophobic ligands; thus, they are believed to be involved with uptake and trafficking of lipids in the intestine. In vitro studies have identified differences in ligand-binding stoichiometry and specificity, and in mechanisms of FA transfer to membranes, and it has been hypothesized that LFABP and IFABP have different functions in the enterocyte. Studies directly comparing LFABP- and IFABP-null mice have revealed markedly different phenotypes, indicating that these proteins indeed have different functions in intestinal lipid metabolism and whole body energy homeostasis. In this review, we discuss the evolving knowledge of the functions of LFABP and IFABP in the intestinal enterocyte.

KW - Fatty acid

KW - Fatty acid-binding protein

KW - IFABP

KW - Intestine

KW - LFABP

KW - Lipid

UR - https://www.scopus.com/pages/publications/84922782211

UR - https://www.scopus.com/pages/publications/84922782211#tab=citedBy

U2 - 10.1016/j.plefa.2014.10.001

DO - 10.1016/j.plefa.2014.10.001

M3 - Article

C2 - 25458898

SN - 0952-3278

VL - 93

SP - 9

EP - 16

JO - Prostaglandins Leukotrienes and Essential Fatty Acids

JF - Prostaglandins Leukotrienes and Essential Fatty Acids

ER -