Environmental stress increases extracellular dopamine in striatum of 6-hydroxydopamine-treated rats: in vivo microdialysis studies

K. A. Keefe, E. M. Stricker, M. J. Zigmond, E. D. Abercrombie

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Bilateral intraventricular injections of 6-hydroxydopamine depleted dopamine (DA) in striatal tissue of rats by 88%. Tail shock increased DA in striatal extracellular fluid of these rats from 10 to 17 pg/20 μl as measured by microdialysis, values less than half those seen in normal striatum. The increase was observed even in rats that were akinetic. DA in extracellular fluid after stress was negatively correlated with behavioral performance. Thus, residual nigrostriatal DA neurons are responsive to stress but do not produce normal DA levels in striatal extracellular fluid.

Original languageEnglish (US)
Pages (from-to)350-353
Number of pages4
JournalBrain Research
Volume527
Issue number2
DOIs
StatePublished - Sep 17 1990
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • 6-Hydroxydopamine
  • Dopamine
  • Microdialysis
  • Neuroplasticity
  • Parkinson's disease
  • Stress
  • Striatum

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