Enzymes for the production of 2-keto-L-gluconic acid

Robert A. Lazarus, Mark Hurle, Stephen Anderson, David B. Powers

Research output: Contribution to journalArticle


Mutants of 2,5-diketo-D-gluconic acid reductase A, an enzyme used to produce 2-keto-L-gulonic acid, a precursor of ascorbic acid (vitamin C) are prepared by site-directed mutagenesis. These mutants have increased catalytic activity, increased expression levels, and/or enhanced temperature stability.

Original languageEnglish (US)
Number of pages1
JournalBiotechnology Advances
Issue number3-4
StatePublished - Jan 1 1997

All Science Journal Classification (ASJC) codes

  • Applied Microbiology and Biotechnology
  • Bioengineering
  • Biotechnology

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