Epithelial membrane antigen expression in breast fluids and 'witch's milk'

Charlene J. Williams; Arnold S. Dion; James Carten; Gertrude C. Buehring

doi:10.1007/BF01975004

Epithelial membrane antigen expression in breast fluids and 'witch's milk'

Charlene J. Williams
, Arnold S. Dion
, James Carten
, Gertrude C. Buehring

Research output: Contribution to journal › Article › peer-review

Abstract

We have examined breast fluids from non-lactating women and male neonates for the expression of epithelial membrane antigen (EMA), also termed polymorphic epithelial mucin (PEM). All fluids exhibited significant amounts of EMA as demonstrated by immunoblot analyses and enzyme immunoassay. EMA was present in the breast fluids of both pre- and post-menopausal women, and these results suggest that nipple aspirates could provide an easily accessible source of antigen for assessing the value of EMA as a tumor marker both before and after various therapeutic modalities. The presence of EMA in the 'witch's milks' indicates that full maturation of the breast is not a prerequisite for antigen expression in breast tissue.

Original language	American English
Pages (from-to)	211-216
Number of pages	6
Journal	Breast Cancer Research and Treatment
Volume	21
Issue number	3
DOIs	https://doi.org/10.1007/BF01975004
State	Published - Oct 1992
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/BF01975004

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title = "Epithelial membrane antigen expression in breast fluids and 'witch's milk'",

abstract = "We have examined breast fluids from non-lactating women and male neonates for the expression of epithelial membrane antigen (EMA), also termed polymorphic epithelial mucin (PEM). All fluids exhibited significant amounts of EMA as demonstrated by immunoblot analyses and enzyme immunoassay. EMA was present in the breast fluids of both pre- and post-menopausal women, and these results suggest that nipple aspirates could provide an easily accessible source of antigen for assessing the value of EMA as a tumor marker both before and after various therapeutic modalities. The presence of EMA in the 'witch's milks' indicates that full maturation of the breast is not a prerequisite for antigen expression in breast tissue.",

author = "Williams, \{Charlene J.\} and Dion, \{Arnold S.\} and James Carten and Buehring, \{Gertrude C.\}",

year = "1992",

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doi = "10.1007/BF01975004",

language = "American English",

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journal = "Breast Cancer Research and Treatment",

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AU - Williams, Charlene J.

AU - Dion, Arnold S.

AU - Carten, James

AU - Buehring, Gertrude C.

PY - 1992/10

Y1 - 1992/10

N2 - We have examined breast fluids from non-lactating women and male neonates for the expression of epithelial membrane antigen (EMA), also termed polymorphic epithelial mucin (PEM). All fluids exhibited significant amounts of EMA as demonstrated by immunoblot analyses and enzyme immunoassay. EMA was present in the breast fluids of both pre- and post-menopausal women, and these results suggest that nipple aspirates could provide an easily accessible source of antigen for assessing the value of EMA as a tumor marker both before and after various therapeutic modalities. The presence of EMA in the 'witch's milks' indicates that full maturation of the breast is not a prerequisite for antigen expression in breast tissue.

AB - We have examined breast fluids from non-lactating women and male neonates for the expression of epithelial membrane antigen (EMA), also termed polymorphic epithelial mucin (PEM). All fluids exhibited significant amounts of EMA as demonstrated by immunoblot analyses and enzyme immunoassay. EMA was present in the breast fluids of both pre- and post-menopausal women, and these results suggest that nipple aspirates could provide an easily accessible source of antigen for assessing the value of EMA as a tumor marker both before and after various therapeutic modalities. The presence of EMA in the 'witch's milks' indicates that full maturation of the breast is not a prerequisite for antigen expression in breast tissue.

UR - https://www.scopus.com/pages/publications/0026691688

UR - https://www.scopus.com/pages/publications/0026691688#tab=citedBy

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SP - 211

EP - 216

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

IS - 3

ER -

Epithelial membrane antigen expression in breast fluids and 'witch's milk'

Abstract

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