Etanercept, anticytokines and mania

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17 Scopus citations


Cytokines influence multiple psychiatric and medical conditions. Proinflammatory cytokines are associated with depression. The novel treatment of autoimmune diseases with anticytokines presents a unique strategy to understand the role of cytokines in affective disorders. Specifically, because antidepressants can be associated with cycling into manic states, and antidepressants can be associated with resolution of cytokine-induced depression, then, hypothetically, the treatment of a vulnerable patient who has an affective disorder with an anticytokine could also result in cycling. The development of a manic episode is described in a patient with psoriatic arthritis who was treated with etanercept, a tumour necrosis factor-α antagonist.

Original languageEnglish (US)
Pages (from-to)239-241
Number of pages3
JournalInternational Clinical Psychopharmacology
Issue number4
StatePublished - Jul 2005

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Pharmacology (medical)


  • Affective disorder
  • Anti-TNF-α
  • Anti-cytokine
  • Autoimmune disease
  • Bipolar disorder
  • Cycling
  • Cytokine
  • Depression
  • Etanercept
  • Mania
  • Psoriasis
  • TNF-α


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