Eukaryotic gene expression: A structuralist's view

Stephen K. Burley

Research output: Contribution to journalArticlepeer-review


Gene expression in eukaryotes is regulated in response to a host of developmental arid environmental signals, which direct individual cells and tissues 10 synthesize spécifie subsets of proteins required for homeostasis. Over the past three decades, biochemists and molecular geneticists have made enormous con tri but ions to our knowledge of I he diverse mechanisms by which gene expression is controlled during transcription, RNA splicing, and translation. At each of these three major synthetic steps en route to the gene product, highly-complex phylogenetically-conserved marornolecular assemblies are responsible for both chemical catalysis and regulation. With recent advances in synchrotron radia tion, high-speed computing, and crystalline sample preparation/preservation, structural biologists are studying large maromolecular assemblies at the level of atomic detail. These structures are having a very considerable intellectual impact. They provide elegant mechanistic explanations for much of what we know, and are changing our experimental approach to molecular biology-.

Original languageEnglish (US)
Pages (from-to)A869
JournalFASEB Journal
Issue number9
StatePublished - 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Molecular Biology
  • Biochemistry
  • Biotechnology


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