Abstract
Current therapies against African and American trypanosomiasis are problematic and with no immediate prospect of a vaccine there is an urgent need for cheap, more effective treatments. To aid the drug discovery pipeline, we report a novel in vivo screening approach using zebrafish (Danio rerio) embryos as a means of rapidly assessing a compounds developmental toxicity. This technique, amenable to high-throughput screening, was validated using several trypanocidal nitroaromatic prodrugs including nifurtimox and benznidazole.
Original language | American English |
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Pages (from-to) | 701-705 |
Number of pages | 5 |
Journal | Acta Tropica |
Volume | 128 |
Issue number | 3 |
DOIs | |
State | Published - Dec 2013 |
ASJC Scopus subject areas
- Parasitology
- veterinary (miscalleneous)
- Insect Science
- Infectious Diseases
Keywords
- Development
- Protozoa
- Toxicity
- Trypanosome
- Zebrafish