Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish

Grace Buchanan-Kilbey; Joshua Djumpah; Maria V. Papadopoulou; William Bloomer; Lonqin Hu; Shane R. Wilkinson; Rachel Ashworth

doi:10.1016/j.actatropica.2013.07.022

Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish

Grace Buchanan-Kilbey, Joshua Djumpah, Maria V. Papadopoulou, William Bloomer, Lonqin Hu, Shane R. Wilkinson, Rachel Ashworth

Ernest Mario School of Pharmacy, Medicinal Chemistry

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Current therapies against African and American trypanosomiasis are problematic and with no immediate prospect of a vaccine there is an urgent need for cheap, more effective treatments. To aid the drug discovery pipeline, we report a novel in vivo screening approach using zebrafish (Danio rerio) embryos as a means of rapidly assessing a compounds developmental toxicity. This technique, amenable to high-throughput screening, was validated using several trypanocidal nitroaromatic prodrugs including nifurtimox and benznidazole.

Original language	American English
Pages (from-to)	701-705
Number of pages	5
Journal	Acta Tropica
Volume	128
Issue number	3
DOIs	https://doi.org/10.1016/j.actatropica.2013.07.022
State	Published - Dec 2013

ASJC Scopus subject areas

Parasitology
veterinary (miscalleneous)
Insect Science
Infectious Diseases

Keywords

Development
Protozoa
Toxicity
Trypanosome
Zebrafish

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10.1016/j.actatropica.2013.07.022

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abstract = "Current therapies against African and American trypanosomiasis are problematic and with no immediate prospect of a vaccine there is an urgent need for cheap, more effective treatments. To aid the drug discovery pipeline, we report a novel in vivo screening approach using zebrafish (Danio rerio) embryos as a means of rapidly assessing a compounds developmental toxicity. This technique, amenable to high-throughput screening, was validated using several trypanocidal nitroaromatic prodrugs including nifurtimox and benznidazole.",

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AU - Buchanan-Kilbey, Grace

AU - Djumpah, Joshua

AU - Papadopoulou, Maria V.

AU - Bloomer, William

AU - Hu, Lonqin

AU - Wilkinson, Shane R.

AU - Ashworth, Rachel

PY - 2013/12

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N2 - Current therapies against African and American trypanosomiasis are problematic and with no immediate prospect of a vaccine there is an urgent need for cheap, more effective treatments. To aid the drug discovery pipeline, we report a novel in vivo screening approach using zebrafish (Danio rerio) embryos as a means of rapidly assessing a compounds developmental toxicity. This technique, amenable to high-throughput screening, was validated using several trypanocidal nitroaromatic prodrugs including nifurtimox and benznidazole.

AB - Current therapies against African and American trypanosomiasis are problematic and with no immediate prospect of a vaccine there is an urgent need for cheap, more effective treatments. To aid the drug discovery pipeline, we report a novel in vivo screening approach using zebrafish (Danio rerio) embryos as a means of rapidly assessing a compounds developmental toxicity. This technique, amenable to high-throughput screening, was validated using several trypanocidal nitroaromatic prodrugs including nifurtimox and benznidazole.

KW - Development

KW - Protozoa

KW - Toxicity

KW - Trypanosome

KW - Zebrafish

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Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish

Abstract

ASJC Scopus subject areas

Keywords

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