Abstract
Current therapies against African and American trypanosomiasis are problematic and with no immediate prospect of a vaccine there is an urgent need for cheap, more effective treatments. To aid the drug discovery pipeline, we report a novel in vivo screening approach using zebrafish (Danio rerio) embryos as a means of rapidly assessing a compounds developmental toxicity. This technique, amenable to high-throughput screening, was validated using several trypanocidal nitroaromatic prodrugs including nifurtimox and benznidazole.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 701-705 |
| Number of pages | 5 |
| Journal | Acta Tropica |
| Volume | 128 |
| Issue number | 3 |
| DOIs | |
| State | Published - Dec 1 2013 |
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All Science Journal Classification (ASJC) codes
- Insect Science
- Infectious Diseases
- veterinary (miscalleneous)
- Parasitology
Keywords
- Development
- Protozoa
- Toxicity
- Trypanosome
- Zebrafish
Cite this
}
Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish. / Buchanan-Kilbey, Grace; Djumpah, Joshua; Papadopoulou, Maria V.; Bloomer, William; Hu, Longqin; Wilkinson, Shane R.; Ashworth, Rachel.
In: Acta Tropica, Vol. 128, No. 3, 01.12.2013, p. 701-705.Research output: Contribution to journal › Article
TY - JOUR
T1 - Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish
AU - Buchanan-Kilbey, Grace
AU - Djumpah, Joshua
AU - Papadopoulou, Maria V.
AU - Bloomer, William
AU - Hu, Longqin
AU - Wilkinson, Shane R.
AU - Ashworth, Rachel
PY - 2013/12/1
Y1 - 2013/12/1
N2 - Current therapies against African and American trypanosomiasis are problematic and with no immediate prospect of a vaccine there is an urgent need for cheap, more effective treatments. To aid the drug discovery pipeline, we report a novel in vivo screening approach using zebrafish (Danio rerio) embryos as a means of rapidly assessing a compounds developmental toxicity. This technique, amenable to high-throughput screening, was validated using several trypanocidal nitroaromatic prodrugs including nifurtimox and benznidazole.
AB - Current therapies against African and American trypanosomiasis are problematic and with no immediate prospect of a vaccine there is an urgent need for cheap, more effective treatments. To aid the drug discovery pipeline, we report a novel in vivo screening approach using zebrafish (Danio rerio) embryos as a means of rapidly assessing a compounds developmental toxicity. This technique, amenable to high-throughput screening, was validated using several trypanocidal nitroaromatic prodrugs including nifurtimox and benznidazole.
KW - Development
KW - Protozoa
KW - Toxicity
KW - Trypanosome
KW - Zebrafish
UR - http://www.scopus.com/inward/record.url?scp=84892490567&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892490567&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.actatropica.2013.07.022
DO - https://doi.org/10.1016/j.actatropica.2013.07.022
M3 - Article
C2 - 23916507
VL - 128
SP - 701
EP - 705
JO - Acta Tropica
JF - Acta Tropica
SN - 0001-706X
IS - 3
ER -