Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish

Grace Buchanan-Kilbey, Joshua Djumpah, Maria V. Papadopoulou, William Bloomer, Longqin Hu, Shane R. Wilkinson, Rachel Ashworth

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Current therapies against African and American trypanosomiasis are problematic and with no immediate prospect of a vaccine there is an urgent need for cheap, more effective treatments. To aid the drug discovery pipeline, we report a novel in vivo screening approach using zebrafish (Danio rerio) embryos as a means of rapidly assessing a compounds developmental toxicity. This technique, amenable to high-throughput screening, was validated using several trypanocidal nitroaromatic prodrugs including nifurtimox and benznidazole.

Original languageEnglish (US)
Pages (from-to)701-705
Number of pages5
JournalActa Tropica
Volume128
Issue number3
DOIs
StatePublished - Dec 1 2013

Fingerprint

developmental toxicity
Zebrafish
Danio rerio
Nifurtimox
African trypanosomiasis
African Trypanosomiasis
screening
Chagas disease
Chagas Disease
Prodrugs
Drug Discovery
African Americans
Vaccines
Embryonic Structures
vaccines
drugs
therapeutics
Therapeutics
nitroaromatic compounds
methodology

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Parasitology

Keywords

  • Development
  • Protozoa
  • Toxicity
  • Trypanosome
  • Zebrafish

Cite this

Buchanan-Kilbey, G., Djumpah, J., Papadopoulou, M. V., Bloomer, W., Hu, L., Wilkinson, S. R., & Ashworth, R. (2013). Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish. Acta Tropica, 128(3), 701-705. https://doi.org/10.1016/j.actatropica.2013.07.022
Buchanan-Kilbey, Grace ; Djumpah, Joshua ; Papadopoulou, Maria V. ; Bloomer, William ; Hu, Longqin ; Wilkinson, Shane R. ; Ashworth, Rachel. / Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish. In: Acta Tropica. 2013 ; Vol. 128, No. 3. pp. 701-705.
@article{6d6d88deaecd4589841df276ded90ecb,
title = "Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish",
abstract = "Current therapies against African and American trypanosomiasis are problematic and with no immediate prospect of a vaccine there is an urgent need for cheap, more effective treatments. To aid the drug discovery pipeline, we report a novel in vivo screening approach using zebrafish (Danio rerio) embryos as a means of rapidly assessing a compounds developmental toxicity. This technique, amenable to high-throughput screening, was validated using several trypanocidal nitroaromatic prodrugs including nifurtimox and benznidazole.",
keywords = "Development, Protozoa, Toxicity, Trypanosome, Zebrafish",
author = "Grace Buchanan-Kilbey and Joshua Djumpah and Papadopoulou, {Maria V.} and William Bloomer and Longqin Hu and Wilkinson, {Shane R.} and Rachel Ashworth",
year = "2013",
month = "12",
day = "1",
doi = "https://doi.org/10.1016/j.actatropica.2013.07.022",
language = "English (US)",
volume = "128",
pages = "701--705",
journal = "Acta Tropica",
issn = "0001-706X",
publisher = "Elsevier",
number = "3",

}

Buchanan-Kilbey, G, Djumpah, J, Papadopoulou, MV, Bloomer, W, Hu, L, Wilkinson, SR & Ashworth, R 2013, 'Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish', Acta Tropica, vol. 128, no. 3, pp. 701-705. https://doi.org/10.1016/j.actatropica.2013.07.022

Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish. / Buchanan-Kilbey, Grace; Djumpah, Joshua; Papadopoulou, Maria V.; Bloomer, William; Hu, Longqin; Wilkinson, Shane R.; Ashworth, Rachel.

In: Acta Tropica, Vol. 128, No. 3, 01.12.2013, p. 701-705.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish

AU - Buchanan-Kilbey, Grace

AU - Djumpah, Joshua

AU - Papadopoulou, Maria V.

AU - Bloomer, William

AU - Hu, Longqin

AU - Wilkinson, Shane R.

AU - Ashworth, Rachel

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Current therapies against African and American trypanosomiasis are problematic and with no immediate prospect of a vaccine there is an urgent need for cheap, more effective treatments. To aid the drug discovery pipeline, we report a novel in vivo screening approach using zebrafish (Danio rerio) embryos as a means of rapidly assessing a compounds developmental toxicity. This technique, amenable to high-throughput screening, was validated using several trypanocidal nitroaromatic prodrugs including nifurtimox and benznidazole.

AB - Current therapies against African and American trypanosomiasis are problematic and with no immediate prospect of a vaccine there is an urgent need for cheap, more effective treatments. To aid the drug discovery pipeline, we report a novel in vivo screening approach using zebrafish (Danio rerio) embryos as a means of rapidly assessing a compounds developmental toxicity. This technique, amenable to high-throughput screening, was validated using several trypanocidal nitroaromatic prodrugs including nifurtimox and benznidazole.

KW - Development

KW - Protozoa

KW - Toxicity

KW - Trypanosome

KW - Zebrafish

UR - http://www.scopus.com/inward/record.url?scp=84892490567&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892490567&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.actatropica.2013.07.022

DO - https://doi.org/10.1016/j.actatropica.2013.07.022

M3 - Article

VL - 128

SP - 701

EP - 705

JO - Acta Tropica

JF - Acta Tropica

SN - 0001-706X

IS - 3

ER -

Buchanan-Kilbey G, Djumpah J, Papadopoulou MV, Bloomer W, Hu L, Wilkinson SR et al. Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish. Acta Tropica. 2013 Dec 1;128(3):701-705. https://doi.org/10.1016/j.actatropica.2013.07.022